article published yes Roger Hasler author Ciril Reiner-Rozman author Stefan Fossati author Patrik Aspermair author Jakub Dostalek author Seungho Lee author BB243B88-D767-11E9-B658-BC13E66974250000-0002-6962-8598 Maria Ibáñez author 43C61214-F248-11E8-B48F-1D18A9856A870000-0001-5013-2843 Johannes Bintinger author Wolfgang Knoll author MaIb department A novel multivariable system, combining a transistor with fiber optic-based surface plasmon resonance spectroscopy with the gate electrode simultaneously acting as the fiber optic sensor surface, is reported. The dual-mode sensor allows for discrimination of mass and charge contributions for binding assays on the same sensor surface. Furthermore, we optimize the sensor geometry by investigating the influence of the fiber area to transistor channel area ratio and distance. We show that larger fiber optic tip diameters are favorable for electronic and optical signals and demonstrate the reversibility of plasmon resonance wavelength shifts after electric field application. As a proof of principle, a layer-by-layer assembly of polyelectrolytes is performed to benchmark the system against multivariable sensing platforms with planar surface plasmon resonance configurations. Furthermore, the biosensing performance is assessed using a thrombin binding assay with surface-immobilized aptamers as receptors, allowing for the detection of medically relevant thrombin concentrations. https://research-explorer.ista.ac.at/download/10829/10832/2022_ACSSensors_Hasler.pdf application/pdfno American Chemical Society2022 eng 2379-3694 35134289 00076511300001610.1021/acssensors.1c02313 72504-512 https://research-explorer.ista.ac.at/record/10833 R. Hasler <i>et al.</i>, “Field-effect transistor with a plasmonic fiber optic gate electrode as a multivariable biosensor device,” <i>ACS Sensors</i>, vol. 7, no. 2. American Chemical Society, pp. 504–512, 2022. Hasler, R., Reiner-Rozman, C., Fossati, S., Aspermair, P., Dostalek, J., Lee, S., … Knoll, W. (2022). Field-effect transistor with a plasmonic fiber optic gate electrode as a multivariable biosensor device. <i>ACS Sensors</i>. American Chemical Society. <a href="https://doi.org/10.1021/acssensors.1c02313">https://doi.org/10.1021/acssensors.1c02313</a> Hasler R, Reiner-Rozman C, Fossati S, Aspermair P, Dostalek J, Lee S, Ibáñez M, Bintinger J, Knoll W. 2022. Field-effect transistor with a plasmonic fiber optic gate electrode as a multivariable biosensor device. ACS Sensors. 7(2), 504–512. Hasler, Roger, et al. “Field-Effect Transistor with a Plasmonic Fiber Optic Gate Electrode as a Multivariable Biosensor Device.” <i>ACS Sensors</i>, vol. 7, no. 2, American Chemical Society, 2022, pp. 504–12, doi:<a href="https://doi.org/10.1021/acssensors.1c02313">10.1021/acssensors.1c02313</a>. Hasler, Roger, Ciril Reiner-Rozman, Stefan Fossati, Patrik Aspermair, Jakub Dostalek, Seungho Lee, Maria Ibáñez, Johannes Bintinger, and Wolfgang Knoll. “Field-Effect Transistor with a Plasmonic Fiber Optic Gate Electrode as a Multivariable Biosensor Device.” <i>ACS Sensors</i>. American Chemical Society, 2022. <a href="https://doi.org/10.1021/acssensors.1c02313">https://doi.org/10.1021/acssensors.1c02313</a>. Hasler R, Reiner-Rozman C, Fossati S, et al. Field-effect transistor with a plasmonic fiber optic gate electrode as a multivariable biosensor device. <i>ACS Sensors</i>. 2022;7(2):504-512. doi:<a href="https://doi.org/10.1021/acssensors.1c02313">10.1021/acssensors.1c02313</a> R. Hasler, C. Reiner-Rozman, S. Fossati, P. Aspermair, J. Dostalek, S. Lee, M. Ibáñez, J. Bintinger, W. Knoll, ACS Sensors 7 (2022) 504–512. 108292022-03-06T23:01:54Z2026-04-02T12:33:46Z