MON-2, a Golgi protein, promotes longevity by upregulating autophagy through mediating inter-organelle communications

article MON-2, a Golgi protein, promotes longevity by upregulating autophagy through mediating inter-organelle communications published yes Murat Artan author C407B586-6052-11E9-B3AE-7006E66974250000-0001-8945-6992 Jooyeon Sohn author Cheolju Lee author Seung Yeol Park author Seung Jae V. Lee author MaDe department The Golgi apparatus regulates the process of modification and subcellular localization of macromolecules, including proteins and lipids. Aberrant protein sorting caused by defects in the Golgi leads to various diseases in mammals. However, the role of the Golgi apparatus in organismal longevity remained largely unknown. By employing a quantitative proteomic approach, we demonstrated that MON-2, an evolutionarily conserved Arf-GEF protein implicated in Golgi-to-endosome trafficking, promotes longevity via upregulating macroautophagy/autophagy in C. elegans. Our data using cultured mammalian cells indicate that MON2 translocates from the Golgi to the endosome under starvation conditions, subsequently increasing autophagic flux by binding LGG-1/GABARAPL2. Thus, Golgi-to-endosome trafficking appears to be an evolutionarily conserved process for the upregulation of autophagy, which contributes to organismal longevity. Taylor & Francis2022 eng Autophagy 1554-8627 1554-8635 35188063 00075885960000110.1080/15548627.2022.2039523 1851208-1210 M. Artan, J. Sohn, C. Lee, S.Y. Park, S.J.V. Lee, Autophagy 18 (2022) 1208–1210. Artan M, Sohn J, Lee C, Park SY, Lee SJV. MON-2, a Golgi protein, promotes longevity by upregulating autophagy through mediating inter-organelle communications. Autophagy. 2022;18(5):1208-1210. doi:<a href="https://doi.org/10.1080/15548627.2022.2039523">10.1080/15548627.2022.2039523</a> Artan, M., Sohn, J., Lee, C., Park, S. Y., & Lee, S. J. V. (2022). MON-2, a Golgi protein, promotes longevity by upregulating autophagy through mediating inter-organelle communications. Autophagy. Taylor & Francis. <a href="https://doi.org/10.1080/15548627.2022.2039523">https://doi.org/10.1080/15548627.2022.2039523</a> Artan, Murat, et al. “MON-2, a Golgi Protein, Promotes Longevity by Upregulating Autophagy through Mediating Inter-Organelle Communications.” Autophagy, vol. 18, no. 5, Taylor & Francis, 2022, pp. 1208–10, doi:<a href="https://doi.org/10.1080/15548627.2022.2039523">10.1080/15548627.2022.2039523</a>. Artan M, Sohn J, Lee C, Park SY, Lee SJV. 2022. MON-2, a Golgi protein, promotes longevity by upregulating autophagy through mediating inter-organelle communications. Autophagy. 18(5), 1208–1210. Artan, Murat, Jooyeon Sohn, Cheolju Lee, Seung Yeol Park, and Seung Jae V. Lee. “MON-2, a Golgi Protein, Promotes Longevity by Upregulating Autophagy through Mediating Inter-Organelle Communications.” Autophagy. Taylor & Francis, 2022. <a href="https://doi.org/10.1080/15548627.2022.2039523">https://doi.org/10.1080/15548627.2022.2039523</a>. M. Artan, J. Sohn, C. Lee, S. Y. Park, and S. J. V. Lee, “MON-2, a Golgi protein, promotes longevity by upregulating autophagy through mediating inter-organelle communications,” Autophagy, vol. 18, no. 5. Taylor & Francis, pp. 1208–1210, 2022. 108462022-03-13T23:01:47Z2023-10-03T10:54:54Z