---
res:
  bibo_abstract:
  - Upon the arrival of action potentials at nerve terminals, neurotransmitters are
    released from synaptic vesicles (SVs) by exocytosis. CaV2.1, 2.2, and 2.3 are
    the major subunits of the voltage-gated calcium channel (VGCC) responsible for
    increasing intraterminal calcium levels and triggering SV exocytosis in the central
    nervous system (CNS) synapses. The two-dimensional analysis of CaV2 distributions
    using sodium dodecyl sulfate (SDS)-digested freeze-fracture replica labeling (SDS-FRL)
    has revealed their numbers, densities, and nanoscale clustering patterns in individual
    presynaptic active zones. The variation in these properties affects the coupling
    of VGCCs with calcium sensors on SVs, synaptic efficacy, and temporal precision
    of transmission. In this study, we summarize how the morphological parameters
    of CaV2 distribution obtained using SDS-FRL differ depending on the different
    types of synapses and could correspond to functional properties in synaptic transmission.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Kohgaku
      foaf_name: Eguchi, Kohgaku
      foaf_surname: Eguchi
      foaf_workInfoHomepage: http://www.librecat.org/personId=2B7846DC-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6170-2546
  - foaf_Person:
      foaf_givenName: Jacqueline-Claire
      foaf_name: Montanaro-Punzengruber, Jacqueline-Claire
      foaf_surname: Montanaro-Punzengruber
      foaf_workInfoHomepage: http://www.librecat.org/personId=3786AB44-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Elodie
      foaf_name: Le Monnier, Elodie
      foaf_surname: Le Monnier
      foaf_workInfoHomepage: http://www.librecat.org/personId=3B59276A-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Ryuichi
      foaf_name: Shigemoto, Ryuichi
      foaf_surname: Shigemoto
      foaf_workInfoHomepage: http://www.librecat.org/personId=499F3ABC-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8761-9444
  bibo_doi: 10.3389/fnana.2022.846615
  bibo_volume: 16
  dct_date: 2022^xs_gYear
  dct_identifier:
  - UT:000766662700001
  dct_isPartOf:
  - http://id.crossref.org/issn/1662-5129
  dct_language: eng
  dct_publisher: Frontiers@
  dct_title: The number and distinct clustering patterns of voltage-gated Calcium
    channels in nerve terminals@
  fabio_hasPubmedId: '35280978'
...