---
res:
  bibo_abstract:
  - Cellular metabolism must adapt to changing demands to enable homeostasis. During
    immune responses or cancer metastasis, cells leading migration into challenging
    environments require an energy boost, but what controls this capacity is unclear.
    Here, we study a previously uncharacterized nuclear protein, Atossa (encoded by
    CG9005), which supports macrophage invasion into the germband of Drosophila by
    controlling cellular metabolism. First, nuclear Atossa increases mRNA levels of
    Porthos, a DEAD-box protein, and of two metabolic enzymes, lysine-α-ketoglutarate
    reductase (LKR/SDH) and NADPH glyoxylate reductase (GR/HPR), thus enhancing mitochondrial
    bioenergetics. Then Porthos supports ribosome assembly and thereby raises the
    translational efficiency of a subset of mRNAs, including those affecting mitochondrial
    functions, the electron transport chain, and metabolism. Mitochondrial respiration
    measurements, metabolomics, and live imaging indicate that Atossa and Porthos
    power up OxPhos and energy production to promote the forging of a path into tissues
    by leading macrophages. Since many crucial physiological responses require increases
    in mitochondrial energy output, this previously undescribed genetic program may
    modulate a wide range of cellular behaviors.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Shamsi
      foaf_name: Emtenani, Shamsi
      foaf_surname: Emtenani
      foaf_workInfoHomepage: http://www.librecat.org/personId=49D32318-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6981-6938
  - foaf_Person:
      foaf_givenName: Elliot T
      foaf_name: Martin, Elliot T
      foaf_surname: Martin
  - foaf_Person:
      foaf_givenName: Attila
      foaf_name: György, Attila
      foaf_surname: György
      foaf_workInfoHomepage: http://www.librecat.org/personId=3BCEDBE0-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-1819-198X
  - foaf_Person:
      foaf_givenName: Julia
      foaf_name: Bicher, Julia
      foaf_surname: Bicher
      foaf_workInfoHomepage: http://www.librecat.org/personId=3CCBB46E-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Jakob-Wendelin
      foaf_name: Genger, Jakob-Wendelin
      foaf_surname: Genger
  - foaf_Person:
      foaf_givenName: Thomas
      foaf_name: Köcher, Thomas
      foaf_surname: Köcher
  - foaf_Person:
      foaf_givenName: Maria
      foaf_name: Akhmanova, Maria
      foaf_surname: Akhmanova
      foaf_workInfoHomepage: http://www.librecat.org/personId=3425EC26-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-1522-3162
  - foaf_Person:
      foaf_givenName: Mariana
      foaf_name: Pereira Guarda, Mariana
      foaf_surname: Pereira Guarda
      foaf_workInfoHomepage: http://www.librecat.org/personId=6de81d9d-e2f2-11eb-945a-af8bc2a60b26
    orcid: 0000-0001-8238-480X
  - foaf_Person:
      foaf_givenName: Marko
      foaf_name: Roblek, Marko
      foaf_surname: Roblek
      foaf_workInfoHomepage: http://www.librecat.org/personId=3047D808-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-9588-1389
  - foaf_Person:
      foaf_givenName: Andreas
      foaf_name: Bergthaler, Andreas
      foaf_surname: Bergthaler
  - foaf_Person:
      foaf_givenName: Thomas R
      foaf_name: Hurd, Thomas R
      foaf_surname: Hurd
  - foaf_Person:
      foaf_givenName: Prashanth
      foaf_name: Rangan, Prashanth
      foaf_surname: Rangan
  - foaf_Person:
      foaf_givenName: Daria E
      foaf_name: Siekhaus, Daria E
      foaf_surname: Siekhaus
      foaf_workInfoHomepage: http://www.librecat.org/personId=3D224B9E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8323-8353
  bibo_doi: 10.15252/embj.2021109049
  bibo_volume: 41
  dct_date: 2022^xs_gYear
  dct_identifier:
  - UT:000771957000001
  dct_isPartOf:
  - http://id.crossref.org/issn/1460-2075
  dct_language: eng
  dct_publisher: Embo Press@
  dct_title: Macrophage mitochondrial bioenergetics and tissue invasion are boosted
    by an Atossa-Porthos axis in Drosophila@
  fabio_hasPubmedId: '35319107'
...