---
res:
  bibo_abstract:
  - During metazoan development, the temporal pattern of morphogen signaling is critical
    for organizing cell fates in space and time. Yet, tools for temporally controlling
    morphogen signaling within the embryo are still scarce. Here, we developed a photoactivatable
    Nodal receptor to determine how the temporal pattern of Nodal signaling affects
    cell fate specification during zebrafish gastrulation. By using this receptor
    to manipulate the duration of Nodal signaling in vivo by light, we show that extended
    Nodal signaling within the organizer promotes prechordal plate specification and
    suppresses endoderm differentiation. Endoderm differentiation is suppressed by
    extended Nodal signaling inducing expression of the transcriptional repressor
    goosecoid (gsc) in prechordal plate progenitors, which in turn restrains Nodal
    signaling from upregulating the endoderm differentiation gene sox17 within these
    cells. Thus, optogenetic manipulation of Nodal signaling identifies a critical
    role of Nodal signaling duration for organizer cell fate specification during
    gastrulation.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Keisuke
      foaf_name: Sako, Keisuke
      foaf_surname: Sako
      foaf_workInfoHomepage: http://www.librecat.org/personId=3BED66BE-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6453-8075
  - foaf_Person:
      foaf_givenName: Saurabh
      foaf_name: Pradhan, Saurabh
      foaf_surname: Pradhan
  - foaf_Person:
      foaf_givenName: Vanessa
      foaf_name: Barone, Vanessa
      foaf_surname: Barone
      foaf_workInfoHomepage: http://www.librecat.org/personId=419EECCC-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-2676-3367
  - foaf_Person:
      foaf_givenName: Álvaro
      foaf_name: Inglés Prieto, Álvaro
      foaf_surname: Inglés Prieto
      foaf_workInfoHomepage: http://www.librecat.org/personId=2A9DB292-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-5409-8571
  - foaf_Person:
      foaf_givenName: Patrick
      foaf_name: Mueller, Patrick
      foaf_surname: Mueller
  - foaf_Person:
      foaf_givenName: Verena
      foaf_name: Ruprecht, Verena
      foaf_surname: Ruprecht
      foaf_workInfoHomepage: http://www.librecat.org/personId=4D71A03A-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-4088-8633
  - foaf_Person:
      foaf_givenName: Daniel
      foaf_name: Capek, Daniel
      foaf_surname: Capek
      foaf_workInfoHomepage: http://www.librecat.org/personId=31C42484-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-5199-9940
  - foaf_Person:
      foaf_givenName: Sanjeev
      foaf_name: Galande, Sanjeev
      foaf_surname: Galande
  - foaf_Person:
      foaf_givenName: Harald L
      foaf_name: Janovjak, Harald L
      foaf_surname: Janovjak
      foaf_workInfoHomepage: http://www.librecat.org/personId=33BA6C30-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8023-9315
  - foaf_Person:
      foaf_givenName: Carl-Philipp J
      foaf_name: Heisenberg, Carl-Philipp J
      foaf_surname: Heisenberg
      foaf_workInfoHomepage: http://www.librecat.org/personId=39427864-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-0912-4566
  bibo_doi: 10.1016/j.celrep.2016.06.036
  bibo_issue: '3'
  bibo_volume: 16
  dct_date: 2016^xs_gYear
  dct_identifier:
  - UT:000380264200024
  dct_language: eng
  dct_publisher: Cell Press@
  dct_title: Optogenetic control of nodal signaling reveals a temporal pattern of
    nodal signaling regulating cell fate specification during gastrulation@
...