Multiplexed computations in retinal ganglion cells of a single type Deny, Stephane Ferrari, Ulisse Mace, Emilie Yger, Pierre Caplette, Romain Picaud, Serge Tkacik, Gasper ; https://orcid.org/0000-0002-6699-1455 Marre, Olivier ddc:571 In the early visual system, cells of the same type perform the same computation in different places of the visual field. How these cells code together a complex visual scene is unclear. A common assumption is that cells of a single-type extract a single-stimulus feature to form a feature map, but this has rarely been observed directly. Using large-scale recordings in the rat retina, we show that a homogeneous population of fast OFF ganglion cells simultaneously encodes two radically different features of a visual scene. Cells close to a moving object code quasilinearly for its position, while distant cells remain largely invariant to the object's position and, instead, respond nonlinearly to changes in the object's speed. We develop a quantitative model that accounts for this effect and identify a disinhibitory circuit that mediates it. Ganglion cells of a single type thus do not code for one, but two features simultaneously. This richer, flexible neural map might also be present in other sensory systems. Nature Publishing Group 2017 info:eu-repo/semantics/article doc-type:article text http://purl.org/coar/resource_type/c_2df8fbb1 https://research-explorer.ista.ac.at/record/1104 https://research-explorer.ista.ac.at/download/1104/5191 Deny S, Ferrari U, Mace E, et al. Multiplexed computations in retinal ganglion cells of a single type. <i>Nature Communications</i>. 2017;8(1). doi:<a href="https://doi.org/10.1038/s41467-017-02159-y">10.1038/s41467-017-02159-y</a> eng info:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-017-02159-y info:eu-repo/semantics/altIdentifier/issn/2041-1723 info:eu-repo/semantics/altIdentifier/wos/000417241200004 info:eu-repo/semantics/openAccess