article published yes Stephane Deny author Ulisse Ferrari author Emilie Mace author Pierre Yger author Romain Caplette author Serge Picaud author Gasper Tkacik author 3D494DCA-F248-11E8-B48F-1D18A9856A870000-0002-6699-1455 Olivier Marre author GaTk department Localization of ion channels and receptors by two and three-dimensional immunoelectron microscopic approaches project Sensitivity to higher-order statistics in natural scenes project In the early visual system, cells of the same type perform the same computation in different places of the visual field. How these cells code together a complex visual scene is unclear. A common assumption is that cells of a single-type extract a single-stimulus feature to form a feature map, but this has rarely been observed directly. Using large-scale recordings in the rat retina, we show that a homogeneous population of fast OFF ganglion cells simultaneously encodes two radically different features of a visual scene. Cells close to a moving object code quasilinearly for its position, while distant cells remain largely invariant to the object's position and, instead, respond nonlinearly to changes in the object's speed. We develop a quantitative model that accounts for this effect and identify a disinhibitory circuit that mediates it. Ganglion cells of a single type thus do not code for one, but two features simultaneously. This richer, flexible neural map might also be present in other sensory systems. https://research-explorer.ista.ac.at/download/1104/5191/IST-2018-921-v1+1_s41467-017-02159-y.pdf application/pdfno https://creativecommons.org/licenses/by/4.0/ Nature Publishing Group2017 eng 2041-1723 00041724120000410.1038/s41467-017-02159-y 81 S. Deny, U. Ferrari, E. Mace, P. Yger, R. Caplette, S. Picaud, G. Tkačik, O. Marre, Nature Communications 8 (2017). Deny, Stephane, Ulisse Ferrari, Emilie Mace, Pierre Yger, Romain Caplette, Serge Picaud, Gašper Tkačik, and Olivier Marre. “Multiplexed Computations in Retinal Ganglion Cells of a Single Type.” <i>Nature Communications</i>. Nature Publishing Group, 2017. <a href="https://doi.org/10.1038/s41467-017-02159-y">https://doi.org/10.1038/s41467-017-02159-y</a>. Deny S, Ferrari U, Mace E, Yger P, Caplette R, Picaud S, Tkačik G, Marre O. 2017. Multiplexed computations in retinal ganglion cells of a single type. Nature Communications. 8(1), 1964. Deny, S., Ferrari, U., Mace, E., Yger, P., Caplette, R., Picaud, S., … Marre, O. (2017). Multiplexed computations in retinal ganglion cells of a single type. <i>Nature Communications</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/s41467-017-02159-y">https://doi.org/10.1038/s41467-017-02159-y</a> Deny S, Ferrari U, Mace E, et al. Multiplexed computations in retinal ganglion cells of a single type. <i>Nature Communications</i>. 2017;8(1). doi:<a href="https://doi.org/10.1038/s41467-017-02159-y">10.1038/s41467-017-02159-y</a> S. Deny <i>et al.</i>, “Multiplexed computations in retinal ganglion cells of a single type,” <i>Nature Communications</i>, vol. 8, no. 1. Nature Publishing Group, 2017. Deny, Stephane, et al. “Multiplexed Computations in Retinal Ganglion Cells of a Single Type.” <i>Nature Communications</i>, vol. 8, no. 1, 1964, Nature Publishing Group, 2017, doi:<a href="https://doi.org/10.1038/s41467-017-02159-y">10.1038/s41467-017-02159-y</a>. 11042018-12-11T11:50:10Z2025-07-10T11:50:05Z