---
_id: '1104'
abstract:
- lang: eng
  text: In the early visual system, cells of the same type perform the same computation
    in different places of the visual field. How these cells code together a complex
    visual scene is unclear. A common assumption is that cells of a single-type extract
    a single-stimulus feature to form a feature map, but this has rarely been observed
    directly. Using large-scale recordings in the rat retina, we show that a homogeneous
    population of fast OFF ganglion cells simultaneously encodes two radically different
    features of a visual scene. Cells close to a moving object code quasilinearly
    for its position, while distant cells remain largely invariant to the object's
    position and, instead, respond nonlinearly to changes in the object's speed. We
    develop a quantitative model that accounts for this effect and identify a disinhibitory
    circuit that mediates it. Ganglion cells of a single type thus do not code for
    one, but two features simultaneously. This richer, flexible neural map might also
    be present in other sensory systems.
article_number: '1964'
article_processing_charge: No
author:
- first_name: Stephane
  full_name: Deny, Stephane
  last_name: Deny
- first_name: Ulisse
  full_name: Ferrari, Ulisse
  last_name: Ferrari
- first_name: Emilie
  full_name: Mace, Emilie
  last_name: Mace
- first_name: Pierre
  full_name: Yger, Pierre
  last_name: Yger
- first_name: Romain
  full_name: Caplette, Romain
  last_name: Caplette
- first_name: Serge
  full_name: Picaud, Serge
  last_name: Picaud
- first_name: Gasper
  full_name: Tkacik, Gasper
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkacik
  orcid: 0000-0002-6699-1455
- first_name: Olivier
  full_name: Marre, Olivier
  last_name: Marre
citation:
  ama: Deny S, Ferrari U, Mace E, et al. Multiplexed computations in retinal ganglion
    cells of a single type. <i>Nature Communications</i>. 2017;8(1). doi:<a href="https://doi.org/10.1038/s41467-017-02159-y">10.1038/s41467-017-02159-y</a>
  apa: Deny, S., Ferrari, U., Mace, E., Yger, P., Caplette, R., Picaud, S., … Marre,
    O. (2017). Multiplexed computations in retinal ganglion cells of a single type.
    <i>Nature Communications</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/s41467-017-02159-y">https://doi.org/10.1038/s41467-017-02159-y</a>
  chicago: Deny, Stephane, Ulisse Ferrari, Emilie Mace, Pierre Yger, Romain Caplette,
    Serge Picaud, Gašper Tkačik, and Olivier Marre. “Multiplexed Computations in Retinal
    Ganglion Cells of a Single Type.” <i>Nature Communications</i>. Nature Publishing
    Group, 2017. <a href="https://doi.org/10.1038/s41467-017-02159-y">https://doi.org/10.1038/s41467-017-02159-y</a>.
  ieee: S. Deny <i>et al.</i>, “Multiplexed computations in retinal ganglion cells
    of a single type,” <i>Nature Communications</i>, vol. 8, no. 1. Nature Publishing
    Group, 2017.
  ista: Deny S, Ferrari U, Mace E, Yger P, Caplette R, Picaud S, Tkačik G, Marre O.
    2017. Multiplexed computations in retinal ganglion cells of a single type. Nature
    Communications. 8(1), 1964.
  mla: Deny, Stephane, et al. “Multiplexed Computations in Retinal Ganglion Cells
    of a Single Type.” <i>Nature Communications</i>, vol. 8, no. 1, 1964, Nature Publishing
    Group, 2017, doi:<a href="https://doi.org/10.1038/s41467-017-02159-y">10.1038/s41467-017-02159-y</a>.
  short: S. Deny, U. Ferrari, E. Mace, P. Yger, R. Caplette, S. Picaud, G. Tkačik,
    O. Marre, Nature Communications 8 (2017).
date_created: 2018-12-11T11:50:10Z
date_published: 2017-12-06T00:00:00Z
date_updated: 2025-07-10T11:50:05Z
day: '06'
ddc:
- '571'
department:
- _id: GaTk
doi: 10.1038/s41467-017-02159-y
ec_funded: 1
external_id:
  isi:
  - '000417241200004'
file:
- access_level: open_access
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:16:06Z
  date_updated: 2018-12-12T10:16:06Z
  file_id: '5191'
  file_name: IST-2018-921-v1+1_s41467-017-02159-y.pdf
  file_size: 2872887
  relation: main_file
file_date_updated: 2018-12-12T10:16:06Z
has_accepted_license: '1'
intvolume: '         8'
isi: 1
issue: '1'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 25CD3DD2-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '604102'
  name: Localization of ion channels and receptors by two and three-dimensional immunoelectron
    microscopic approaches
- _id: 254D1A94-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P 25651-N26
  name: Sensitivity to higher-order statistics in natural scenes
publication: Nature Communications
publication_identifier:
  issn:
  - 2041-1723
publication_status: published
publisher: Nature Publishing Group
publist_id: '6266'
pubrep_id: '921'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Multiplexed computations in retinal ganglion cells of a single type
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2017'
...