---
res:
  bibo_abstract:
  - In order to combat molecular damage, most cellular proteins undergo rapid turnover.
    We have previously identified large nuclear protein assemblies that can persist
    for years in post-mitotic tissues and are subject to age-related decline. Here,
    we report that mitochondria can be long lived in the mouse brain and reveal that
    specific mitochondrial proteins have half-lives longer than the average proteome.
    These mitochondrial long-lived proteins (mitoLLPs) are core components of the
    electron transport chain (ETC) and display increased longevity in respiratory
    supercomplexes. We find that COX7C, a mitoLLP that forms a stable contact site
    between complexes I and IV, is required for complex IV and supercomplex assembly.
    Remarkably, even upon depletion of COX7C transcripts, ETC function is maintained
    for days, effectively uncoupling mitochondrial function from ongoing transcription
    of its mitoLLPs. Our results suggest that modulating protein longevity within
    the ETC is critical for mitochondrial proteome maintenance and the robustness
    of mitochondrial function.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Shefali
      foaf_name: Krishna, Shefali
      foaf_surname: Krishna
  - foaf_Person:
      foaf_givenName: Rafael
      foaf_name: Arrojo e Drigo, Rafael
      foaf_surname: Arrojo e Drigo
  - foaf_Person:
      foaf_givenName: Juliana S.
      foaf_name: Capitanio, Juliana S.
      foaf_surname: Capitanio
  - foaf_Person:
      foaf_givenName: Ranjan
      foaf_name: Ramachandra, Ranjan
      foaf_surname: Ramachandra
  - foaf_Person:
      foaf_givenName: Mark
      foaf_name: Ellisman, Mark
      foaf_surname: Ellisman
  - foaf_Person:
      foaf_givenName: Martin W
      foaf_name: HETZER, Martin W
      foaf_surname: HETZER
      foaf_workInfoHomepage: http://www.librecat.org/personId=86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
    orcid: 0000-0002-2111-992X
  bibo_doi: 10.1016/j.devcel.2021.10.008
  bibo_issue: '21'
  bibo_volume: 56
  dct_date: 2021^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/1534-5807
  dct_language: eng
  dct_publisher: Elsevier@
  dct_subject:
  - Developmental Biology
  - Cell Biology
  - General Biochemistry
  - Genetics and Molecular Biology
  - Molecular Biology
  dct_title: Identification of long-lived proteins in the mitochondria reveals increased
    stability of the electron transport chain@
  fabio_hasPubmedId: '34715012'
...