---
_id: '11054'
abstract:
- lang: eng
  text: In recent years, the nuclear pore complex (NPC) has emerged as a key player
    in genome regulation and cellular homeostasis. New discoveries have revealed that
    the NPC has multiple cellular functions besides mediating the molecular exchange
    between the nucleus and the cytoplasm. In this review, we discuss non-transport
    aspects of the NPC focusing on the NPC-genome interaction, the extreme longevity
    of the NPC proteins, and NPC dysfunction in age-related diseases. The examples
    summarized herein demonstrate that the NPC, which first evolved to enable the
    biochemical communication between the nucleus and the cytoplasm, now doubles as
    the gatekeeper of cellular identity and aging.
article_processing_charge: No
article_type: review
author:
- first_name: Ukrae H.
  full_name: Cho, Ukrae H.
  last_name: Cho
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
citation:
  ama: 'Cho UH, Hetzer M. Nuclear periphery takes center stage: The role of nuclear
    pore complexes in cell identity and aging. <i>Neuron</i>. 2020;106(6):899-911.
    doi:<a href="https://doi.org/10.1016/j.neuron.2020.05.031">10.1016/j.neuron.2020.05.031</a>'
  apa: 'Cho, U. H., &#38; Hetzer, M. (2020). Nuclear periphery takes center stage:
    The role of nuclear pore complexes in cell identity and aging. <i>Neuron</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.neuron.2020.05.031">https://doi.org/10.1016/j.neuron.2020.05.031</a>'
  chicago: 'Cho, Ukrae H., and Martin Hetzer. “Nuclear Periphery Takes Center Stage:
    The Role of Nuclear Pore Complexes in Cell Identity and Aging.” <i>Neuron</i>.
    Elsevier, 2020. <a href="https://doi.org/10.1016/j.neuron.2020.05.031">https://doi.org/10.1016/j.neuron.2020.05.031</a>.'
  ieee: 'U. H. Cho and M. Hetzer, “Nuclear periphery takes center stage: The role
    of nuclear pore complexes in cell identity and aging,” <i>Neuron</i>, vol. 106,
    no. 6. Elsevier, pp. 899–911, 2020.'
  ista: 'Cho UH, Hetzer M. 2020. Nuclear periphery takes center stage: The role of
    nuclear pore complexes in cell identity and aging. Neuron. 106(6), 899–911.'
  mla: 'Cho, Ukrae H., and Martin Hetzer. “Nuclear Periphery Takes Center Stage: The
    Role of Nuclear Pore Complexes in Cell Identity and Aging.” <i>Neuron</i>, vol.
    106, no. 6, Elsevier, 2020, pp. 899–911, doi:<a href="https://doi.org/10.1016/j.neuron.2020.05.031">10.1016/j.neuron.2020.05.031</a>.'
  short: U.H. Cho, M. Hetzer, Neuron 106 (2020) 899–911.
date_created: 2022-04-07T07:43:36Z
date_published: 2020-06-17T00:00:00Z
date_updated: 2024-10-14T11:15:26Z
day: '17'
doi: 10.1016/j.neuron.2020.05.031
extern: '1'
external_id:
  pmid:
  - '32553207'
intvolume: '       106'
issue: '6'
keyword:
- General Neuroscience
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.neuron.2020.05.031
month: '06'
oa: 1
oa_version: Published Version
page: 899-911
pmid: 1
publication: Neuron
publication_identifier:
  issn:
  - 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Nuclear periphery takes center stage: The role of nuclear pore complexes in
  cell identity and aging'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 106
year: '2020'
...