---
res:
  bibo_abstract:
  - Nucleoporin 93 (Nup93) expression inversely correlates with the survival of triple-negative
    breast cancer patients. However, our knowledge of Nup93 function in breast cancer
    besides its role as structural component of the nuclear pore complex is not understood.
    Combination of functional assays and genetic analyses suggested that chromatin
    interaction of Nup93 partially modulates the expression of genes associated with
    actin cytoskeleton remodeling and epithelial to mesenchymal transition, resulting
    in impaired invasion of triple-negative, claudin-low breast cancer cells. Nup93
    depletion induced stress fiber formation associated with reduced cell migration/proliferation
    and impaired expression of mesenchymal-like genes. Silencing LIMCH1, a gene responsible
    for actin cytoskeleton remodeling and up-regulated upon Nup93 depletion, partially
    restored the invasive phenotype of cancer cells. Loss of Nup93 led to significant
    defects in tumor establishment/propagation in vivo, whereas patient samples revealed
    that high Nup93 and low LIMCH1 expression correlate with late tumor stage. Our
    approach identified Nup93 as contributor of triple-negative, claudin-low breast
    cancer cell invasion and paves the way to study the role of nuclear envelope proteins
    during breast cancer tumorigenesis.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Simone
      foaf_name: Bersini, Simone
      foaf_surname: Bersini
  - foaf_Person:
      foaf_givenName: Nikki K
      foaf_name: Lytle, Nikki K
      foaf_surname: Lytle
  - foaf_Person:
      foaf_givenName: Roberta
      foaf_name: Schulte, Roberta
      foaf_surname: Schulte
  - foaf_Person:
      foaf_givenName: Ling
      foaf_name: Huang, Ling
      foaf_surname: Huang
  - foaf_Person:
      foaf_givenName: Geoffrey M
      foaf_name: Wahl, Geoffrey M
      foaf_surname: Wahl
  - foaf_Person:
      foaf_givenName: Martin W
      foaf_name: HETZER, Martin W
      foaf_surname: HETZER
      foaf_workInfoHomepage: http://www.librecat.org/personId=86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
    orcid: 0000-0002-2111-992X
  bibo_doi: 10.26508/lsa.201900623
  bibo_issue: '1'
  bibo_volume: 3
  dct_date: 2020^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/2575-1077
  dct_language: eng
  dct_publisher: Life Science Alliance@
  dct_subject:
  - Health
  - Toxicology and Mutagenesis
  - Plant Science
  - Biochemistry
  - Genetics and Molecular Biology (miscellaneous)
  - Ecology
  dct_title: Nup93 regulates breast tumor growth by modulating cell proliferation
    and actin cytoskeleton remodeling@
  fabio_hasPubmedId: '31959624'
...