---
_id: '11058'
abstract:
- lang: eng
  text: Nucleoporin 93 (Nup93) expression inversely correlates with the survival of
    triple-negative breast cancer patients. However, our knowledge of Nup93 function
    in breast cancer besides its role as structural component of the nuclear pore
    complex is not understood. Combination of functional assays and genetic analyses
    suggested that chromatin interaction of Nup93 partially modulates the expression
    of genes associated with actin cytoskeleton remodeling and epithelial to mesenchymal
    transition, resulting in impaired invasion of triple-negative, claudin-low breast
    cancer cells. Nup93 depletion induced stress fiber formation associated with reduced
    cell migration/proliferation and impaired expression of mesenchymal-like genes.
    Silencing LIMCH1, a gene responsible for actin cytoskeleton remodeling and up-regulated
    upon Nup93 depletion, partially restored the invasive phenotype of cancer cells.
    Loss of Nup93 led to significant defects in tumor establishment/propagation in
    vivo, whereas patient samples revealed that high Nup93 and low LIMCH1 expression
    correlate with late tumor stage. Our approach identified Nup93 as contributor
    of triple-negative, claudin-low breast cancer cell invasion and paves the way
    to study the role of nuclear envelope proteins during breast cancer tumorigenesis.
article_number: e201900623
article_processing_charge: No
article_type: original
author:
- first_name: Simone
  full_name: Bersini, Simone
  last_name: Bersini
- first_name: Nikki K
  full_name: Lytle, Nikki K
  last_name: Lytle
- first_name: Roberta
  full_name: Schulte, Roberta
  last_name: Schulte
- first_name: Ling
  full_name: Huang, Ling
  last_name: Huang
- first_name: Geoffrey M
  full_name: Wahl, Geoffrey M
  last_name: Wahl
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
citation:
  ama: Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer M. Nup93 regulates
    breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling.
    <i>Life Science Alliance</i>. 2020;3(1). doi:<a href="https://doi.org/10.26508/lsa.201900623">10.26508/lsa.201900623</a>
  apa: Bersini, S., Lytle, N. K., Schulte, R., Huang, L., Wahl, G. M., &#38; Hetzer,
    M. (2020). Nup93 regulates breast tumor growth by modulating cell proliferation
    and actin cytoskeleton remodeling. <i>Life Science Alliance</i>. Life Science
    Alliance. <a href="https://doi.org/10.26508/lsa.201900623">https://doi.org/10.26508/lsa.201900623</a>
  chicago: Bersini, Simone, Nikki K Lytle, Roberta Schulte, Ling Huang, Geoffrey M
    Wahl, and Martin Hetzer. “Nup93 Regulates Breast Tumor Growth by Modulating Cell
    Proliferation and Actin Cytoskeleton Remodeling.” <i>Life Science Alliance</i>.
    Life Science Alliance, 2020. <a href="https://doi.org/10.26508/lsa.201900623">https://doi.org/10.26508/lsa.201900623</a>.
  ieee: S. Bersini, N. K. Lytle, R. Schulte, L. Huang, G. M. Wahl, and M. Hetzer,
    “Nup93 regulates breast tumor growth by modulating cell proliferation and actin
    cytoskeleton remodeling,” <i>Life Science Alliance</i>, vol. 3, no. 1. Life Science
    Alliance, 2020.
  ista: Bersini S, Lytle NK, Schulte R, Huang L, Wahl GM, Hetzer M. 2020. Nup93 regulates
    breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling.
    Life Science Alliance. 3(1), e201900623.
  mla: Bersini, Simone, et al. “Nup93 Regulates Breast Tumor Growth by Modulating
    Cell Proliferation and Actin Cytoskeleton Remodeling.” <i>Life Science Alliance</i>,
    vol. 3, no. 1, e201900623, Life Science Alliance, 2020, doi:<a href="https://doi.org/10.26508/lsa.201900623">10.26508/lsa.201900623</a>.
  short: S. Bersini, N.K. Lytle, R. Schulte, L. Huang, G.M. Wahl, M. Hetzer, Life
    Science Alliance 3 (2020).
date_created: 2022-04-07T07:44:18Z
date_published: 2020-01-01T00:00:00Z
date_updated: 2024-10-14T11:18:41Z
day: '01'
ddc:
- '570'
doi: 10.26508/lsa.201900623
extern: '1'
external_id:
  pmid:
  - '31959624'
file:
- access_level: open_access
  checksum: 3bf33e7e93bef7823287807206b69b38
  content_type: application/pdf
  creator: dernst
  date_created: 2022-04-08T07:33:01Z
  date_updated: 2022-04-08T07:33:01Z
  file_id: '11137'
  file_name: 2020_LifeScienceAlliance_Bersini.pdf
  file_size: 2653960
  relation: main_file
  success: 1
file_date_updated: 2022-04-08T07:33:01Z
fulldoi: https://doi.org/10.26508/lsa.201900623
has_accepted_license: '1'
intvolume: '         3'
issue: '1'
keyword:
- Health
- Toxicology and Mutagenesis
- Plant Science
- Biochemistry
- Genetics and Molecular Biology (miscellaneous)
- Ecology
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
publication: Life Science Alliance
publication_identifier:
  issn:
  - 2575-1077
publication_status: published
publisher: Life Science Alliance
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nup93 regulates breast tumor growth by modulating cell proliferation and actin
  cytoskeleton remodeling
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2020'
...