--- _id: '11071' abstract: - lang: eng text: Nuclear pore complexes (NPCs) emerged as nuclear transport channels in eukaryotic cells ∼1.5 billion years ago. While the primary role of NPCs is to regulate nucleo–cytoplasmic transport, recent research suggests that certain NPC proteins have additionally acquired the role of affecting gene expression at the nuclear periphery and in the nucleoplasm in metazoans. Here we identify a widely expressed variant of the transmembrane nucleoporin (Nup) Pom121 (named sPom121, for “soluble Pom121”) that arose by genomic rearrangement before the divergence of hominoids. sPom121 lacks the nuclear membrane-anchoring domain and thus does not localize to the NPC. Instead, sPom121 colocalizes and interacts with nucleoplasmic Nup98, a previously identified transcriptional regulator, at gene promoters to control transcription of its target genes in human cells. Interestingly, sPom121 transcripts appear independently in several mammalian species, suggesting convergent innovation of Nup-mediated transcription regulation during mammalian evolution. Our findings implicate alternate transcription initiation as a mechanism to increase the functional diversity of NPC components. article_processing_charge: No article_type: original author: - first_name: Tobias M. full_name: Franks, Tobias M. last_name: Franks - first_name: Chris full_name: Benner, Chris last_name: Benner - first_name: Iñigo full_name: Narvaiza, Iñigo last_name: Narvaiza - first_name: Maria C.N. full_name: Marchetto, Maria C.N. last_name: Marchetto - first_name: Janet M. full_name: Young, Janet M. last_name: Young - first_name: Harmit S. full_name: Malik, Harmit S. last_name: Malik - first_name: Fred H. full_name: Gage, Fred H. last_name: Gage - first_name: Martin W full_name: HETZER, Martin W id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed last_name: HETZER orcid: 0000-0002-2111-992X citation: ama: Franks TM, Benner C, Narvaiza I, et al. Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes & Development. 2016;30(10):1155-1171. doi:10.1101/gad.280941.116 apa: Franks, T. M., Benner, C., Narvaiza, I., Marchetto, M. C. N., Young, J. M., Malik, H. S., … Hetzer, M. (2016). Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes & Development. Cold Spring Harbor Laboratory. https://doi.org/10.1101/gad.280941.116 chicago: Franks, Tobias M., Chris Benner, Iñigo Narvaiza, Maria C.N. Marchetto, Janet M. Young, Harmit S. Malik, Fred H. Gage, and Martin Hetzer. “Evolution of a Transcriptional Regulator from a Transmembrane Nucleoporin.” Genes & Development. Cold Spring Harbor Laboratory, 2016. https://doi.org/10.1101/gad.280941.116. ieee: T. M. Franks et al., “Evolution of a transcriptional regulator from a transmembrane nucleoporin,” Genes & Development, vol. 30, no. 10. Cold Spring Harbor Laboratory, pp. 1155–1171, 2016. ista: Franks TM, Benner C, Narvaiza I, Marchetto MCN, Young JM, Malik HS, Gage FH, Hetzer M. 2016. Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes & Development. 30(10), 1155–1171. mla: Franks, Tobias M., et al. “Evolution of a Transcriptional Regulator from a Transmembrane Nucleoporin.” Genes & Development, vol. 30, no. 10, Cold Spring Harbor Laboratory, 2016, pp. 1155–71, doi:10.1101/gad.280941.116. short: T.M. Franks, C. Benner, I. Narvaiza, M.C.N. Marchetto, J.M. Young, H.S. Malik, F.H. Gage, M. Hetzer, Genes & Development 30 (2016) 1155–1171. date_created: 2022-04-07T07:48:20Z date_published: 2016-05-19T00:00:00Z date_updated: 2022-07-18T08:33:50Z day: '19' doi: 10.1101/gad.280941.116 extern: '1' external_id: pmid: - '27198230' intvolume: ' 30' issue: '10' keyword: - Developmental Biology - Genetics language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1101/gad.280941.116 month: '05' oa: 1 oa_version: Published Version page: 1155-1171 pmid: 1 publication: Genes & Development publication_identifier: eissn: - 1549-5477 issn: - 0890-9369 publication_status: published publisher: Cold Spring Harbor Laboratory quality_controlled: '1' scopus_import: '1' status: public title: Evolution of a transcriptional regulator from a transmembrane nucleoporin type: journal_article user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd volume: 30 year: '2016' ...