---
_id: '11078'
abstract:
- lang: eng
  text: Aging is associated with the decline of protein, cell, and organ function.
    Here, we use an integrated approach to characterize gene expression, bulk translation,
    and cell biology in the brains and livers of young and old rats. We identify 468
    differences in protein abundance between young and old animals. The majority are
    a consequence of altered translation output, that is, the combined effect of changes
    in transcript abundance and translation efficiency. In addition, we identify 130
    proteins whose overall abundance remains unchanged but whose sub-cellular localization,
    phosphorylation state, or splice-form varies. While some protein-level differences
    appear to be a generic property of the rats’ chronological age, the majority are
    specific to one organ. These may be a consequence of the organ’s physiology or
    the chronological age of the cells within the tissue. Taken together, our study
    provides an initial view of the proteome at the molecular, sub-cellular, and organ
    level in young and old rats.
article_processing_charge: No
article_type: original
author:
- first_name: Alessandro
  full_name: Ori, Alessandro
  last_name: Ori
- first_name: Brandon H.
  full_name: Toyama, Brandon H.
  last_name: Toyama
- first_name: Michael S.
  full_name: Harris, Michael S.
  last_name: Harris
- first_name: Thomas
  full_name: Bock, Thomas
  last_name: Bock
- first_name: Murat
  full_name: Iskar, Murat
  last_name: Iskar
- first_name: Peer
  full_name: Bork, Peer
  last_name: Bork
- first_name: Nicholas T.
  full_name: Ingolia, Nicholas T.
  last_name: Ingolia
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
- first_name: Martin
  full_name: Beck, Martin
  last_name: Beck
citation:
  ama: Ori A, Toyama BH, Harris MS, et al. Integrated transcriptome and proteome analyses
    reveal organ-specific proteome deterioration in old rats. <i>Cell Systems</i>.
    2015;1(3):P224-237. doi:<a href="https://doi.org/10.1016/j.cels.2015.08.012">10.1016/j.cels.2015.08.012</a>
  apa: Ori, A., Toyama, B. H., Harris, M. S., Bock, T., Iskar, M., Bork, P., … Beck,
    M. (2015). Integrated transcriptome and proteome analyses reveal organ-specific
    proteome deterioration in old rats. <i>Cell Systems</i>. Elsevier. <a href="https://doi.org/10.1016/j.cels.2015.08.012">https://doi.org/10.1016/j.cels.2015.08.012</a>
  chicago: Ori, Alessandro, Brandon H. Toyama, Michael S. Harris, Thomas Bock, Murat
    Iskar, Peer Bork, Nicholas T. Ingolia, Martin Hetzer, and Martin Beck. “Integrated
    Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration
    in Old Rats.” <i>Cell Systems</i>. Elsevier, 2015. <a href="https://doi.org/10.1016/j.cels.2015.08.012">https://doi.org/10.1016/j.cels.2015.08.012</a>.
  ieee: A. Ori <i>et al.</i>, “Integrated transcriptome and proteome analyses reveal
    organ-specific proteome deterioration in old rats,” <i>Cell Systems</i>, vol.
    1, no. 3. Elsevier, pp. P224-237, 2015.
  ista: Ori A, Toyama BH, Harris MS, Bock T, Iskar M, Bork P, Ingolia NT, Hetzer M,
    Beck M. 2015. Integrated transcriptome and proteome analyses reveal organ-specific
    proteome deterioration in old rats. Cell Systems. 1(3), P224-237.
  mla: Ori, Alessandro, et al. “Integrated Transcriptome and Proteome Analyses Reveal
    Organ-Specific Proteome Deterioration in Old Rats.” <i>Cell Systems</i>, vol.
    1, no. 3, Elsevier, 2015, pp. P224-237, doi:<a href="https://doi.org/10.1016/j.cels.2015.08.012">10.1016/j.cels.2015.08.012</a>.
  short: A. Ori, B.H. Toyama, M.S. Harris, T. Bock, M. Iskar, P. Bork, N.T. Ingolia,
    M. Hetzer, M. Beck, Cell Systems 1 (2015) P224-237.
date_created: 2022-04-07T07:49:39Z
date_published: 2015-09-23T00:00:00Z
date_updated: 2024-10-14T11:23:01Z
day: '23'
doi: 10.1016/j.cels.2015.08.012
extern: '1'
external_id:
  pmid:
  - '27135913'
intvolume: '         1'
issue: '3'
keyword:
- Cell Biology
- Histology
- Pathology and Forensic Medicine
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.cels.2015.08.012
month: '09'
oa: 1
oa_version: Published Version
page: P224-237
pmid: 1
publication: Cell Systems
publication_identifier:
  issn:
  - 2405-4712
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Integrated transcriptome and proteome analyses reveal organ-specific proteome
  deterioration in old rats
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1
year: '2015'
...