{"month":"04","publication_status":"published","date_published":"2014-04-21T00:00:00Z","abstract":[{"text":"In eukaryotic cells the nuclear genome is enclosed by the nuclear envelope (NE). In metazoans, the NE breaks down in mitosis and it has been assumed that the physical barrier separating nucleoplasm and cytoplasm remains intact during the rest of the cell cycle and cell differentiation. However, recent studies suggest that nonmitotic NE remodeling plays a critical role in development, virus infection, laminopathies, and cancer. Although the mechanisms underlying these NE restructuring events are currently being defined, one common theme is activation of protein kinase C family members in the interphase nucleus to disrupt the nuclear lamina, demonstrating the importance of the lamina in maintaining nuclear integrity.","lang":"eng"}],"page":"133-141","intvolume":"       205","scopus_import":"1","date_updated":"2022-07-18T08:45:09Z","day":"21","volume":205,"oa_version":"Published Version","publisher":"Rockefeller University Press","year":"2014","type":"journal_article","citation":{"ama":"Hatch E, Hetzer M. Breaching the nuclear envelope in development and disease. <i>Journal of Cell Biology</i>. 2014;205(2):133-141. doi:<a href=\"https://doi.org/10.1083/jcb.201402003\">10.1083/jcb.201402003</a>","ieee":"E. Hatch and M. Hetzer, “Breaching the nuclear envelope in development and disease,” <i>Journal of Cell Biology</i>, vol. 205, no. 2. Rockefeller University Press, pp. 133–141, 2014.","mla":"Hatch, Emily, and Martin Hetzer. “Breaching the Nuclear Envelope in Development and Disease.” <i>Journal of Cell Biology</i>, vol. 205, no. 2, Rockefeller University Press, 2014, pp. 133–41, doi:<a href=\"https://doi.org/10.1083/jcb.201402003\">10.1083/jcb.201402003</a>.","chicago":"Hatch, Emily, and Martin Hetzer. “Breaching the Nuclear Envelope in Development and Disease.” <i>Journal of Cell Biology</i>. Rockefeller University Press, 2014. <a href=\"https://doi.org/10.1083/jcb.201402003\">https://doi.org/10.1083/jcb.201402003</a>.","ista":"Hatch E, Hetzer M. 2014. Breaching the nuclear envelope in development and disease. Journal of Cell Biology. 205(2), 133–141.","apa":"Hatch, E., &#38; Hetzer, M. (2014). Breaching the nuclear envelope in development and disease. <i>Journal of Cell Biology</i>. Rockefeller University Press. <a href=\"https://doi.org/10.1083/jcb.201402003\">https://doi.org/10.1083/jcb.201402003</a>","short":"E. Hatch, M. Hetzer, Journal of Cell Biology 205 (2014) 133–141."},"extern":"1","date_created":"2022-04-07T07:50:13Z","status":"public","article_processing_charge":"No","author":[{"full_name":"Hatch, Emily","last_name":"Hatch","first_name":"Emily"},{"last_name":"HETZER","full_name":"HETZER, Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","orcid":"0000-0002-2111-992X","first_name":"Martin W"}],"title":"Breaching the nuclear envelope in development and disease","issue":"2","article_type":"review","publication":"Journal of Cell Biology","doi":"10.1083/jcb.201402003","quality_controlled":"1","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","external_id":{"pmid":["24751535"]},"_id":"11081","pmid":1,"keyword":["Cell Biology"],"oa":1,"language":[{"iso":"eng"}],"publication_identifier":{"issn":["1540-8140","0021-9525"]},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1083/jcb.201402003"}]}