---
_id: '11081'
abstract:
- lang: eng
  text: In eukaryotic cells the nuclear genome is enclosed by the nuclear envelope
    (NE). In metazoans, the NE breaks down in mitosis and it has been assumed that
    the physical barrier separating nucleoplasm and cytoplasm remains intact during
    the rest of the cell cycle and cell differentiation. However, recent studies suggest
    that nonmitotic NE remodeling plays a critical role in development, virus infection,
    laminopathies, and cancer. Although the mechanisms underlying these NE restructuring
    events are currently being defined, one common theme is activation of protein
    kinase C family members in the interphase nucleus to disrupt the nuclear lamina,
    demonstrating the importance of the lamina in maintaining nuclear integrity.
article_processing_charge: No
article_type: review
author:
- first_name: Emily
  full_name: Hatch, Emily
  last_name: Hatch
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
citation:
  ama: Hatch E, Hetzer M. Breaching the nuclear envelope in development and disease.
    <i>Journal of Cell Biology</i>. 2014;205(2):133-141. doi:<a href="https://doi.org/10.1083/jcb.201402003">10.1083/jcb.201402003</a>
  apa: Hatch, E., &#38; Hetzer, M. (2014). Breaching the nuclear envelope in development
    and disease. <i>Journal of Cell Biology</i>. Rockefeller University Press. <a
    href="https://doi.org/10.1083/jcb.201402003">https://doi.org/10.1083/jcb.201402003</a>
  chicago: Hatch, Emily, and Martin Hetzer. “Breaching the Nuclear Envelope in Development
    and Disease.” <i>Journal of Cell Biology</i>. Rockefeller University Press, 2014.
    <a href="https://doi.org/10.1083/jcb.201402003">https://doi.org/10.1083/jcb.201402003</a>.
  ieee: E. Hatch and M. Hetzer, “Breaching the nuclear envelope in development and
    disease,” <i>Journal of Cell Biology</i>, vol. 205, no. 2. Rockefeller University
    Press, pp. 133–141, 2014.
  ista: Hatch E, Hetzer M. 2014. Breaching the nuclear envelope in development and
    disease. Journal of Cell Biology. 205(2), 133–141.
  mla: Hatch, Emily, and Martin Hetzer. “Breaching the Nuclear Envelope in Development
    and Disease.” <i>Journal of Cell Biology</i>, vol. 205, no. 2, Rockefeller University
    Press, 2014, pp. 133–41, doi:<a href="https://doi.org/10.1083/jcb.201402003">10.1083/jcb.201402003</a>.
  short: E. Hatch, M. Hetzer, Journal of Cell Biology 205 (2014) 133–141.
date_created: 2022-04-07T07:50:13Z
date_published: 2014-04-21T00:00:00Z
date_updated: 2024-10-14T11:23:23Z
day: '21'
doi: 10.1083/jcb.201402003
extern: '1'
external_id:
  pmid:
  - '24751535'
intvolume: '       205'
issue: '2'
keyword:
- Cell Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1083/jcb.201402003
month: '04'
oa: 1
oa_version: Published Version
page: 133-141
pmid: 1
publication: Journal of Cell Biology
publication_identifier:
  issn:
  - 1540-8140
  - 0021-9525
publication_status: published
publisher: Rockefeller University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Breaching the nuclear envelope in development and disease
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 205
year: '2014'
...