---
res:
  bibo_abstract:
  - The nuclear pore complex (NPC) plays a critical role in gene expression by mediating
    import of transcription regulators into the nucleus and export of RNA transcripts
    to the cytoplasm. Emerging evidence suggests that in addition to mediating transport,
    a subset of nucleoporins (Nups) engage in transcriptional activation and elongation
    at genomic loci that are not associated with NPCs. The underlying mechanism and
    regulation of Nup mobility on and off nuclear pores remain unclear. Here we show
    that Nup50 is a mobile Nup with a pronounced presence both at the NPC and in the
    nucleoplasm that can move between these different localizations. Strikingly, the
    dynamic behavior of Nup50 in both locations is dependent on active transcription
    by RNA polymerase II and requires the N-terminal half of the protein, which contains
    importin α– and Nup153-binding domains. However, Nup50 dynamics are independent
    of importin α, Nup153, and Nup98, even though the latter two proteins also exhibit
    transcription-dependent mobility. Of interest, depletion of Nup50 from C2C12 myoblasts
    does not affect cell proliferation but inhibits differentiation into myotubes.
    Taken together, our results suggest a transport-independent role for Nup50 in
    chromatin biology that occurs away from the NPC.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Abigail L.
      foaf_name: Buchwalter, Abigail L.
      foaf_surname: Buchwalter
  - foaf_Person:
      foaf_givenName: Yun
      foaf_name: Liang, Yun
      foaf_surname: Liang
  - foaf_Person:
      foaf_givenName: Martin W
      foaf_name: HETZER, Martin W
      foaf_surname: HETZER
      foaf_workInfoHomepage: http://www.librecat.org/personId=86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
    orcid: 0000-0002-2111-992X
  bibo_doi: 10.1091/mbc.e14-04-0865
  bibo_issue: '16'
  bibo_volume: 25
  dct_date: 2014^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/1059-1524
  - http://id.crossref.org/issn/1939-4586
  dct_language: eng
  dct_publisher: American Society for Cell Biology@
  dct_subject:
  - Cell Biology
  - Molecular Biology
  dct_title: Nup50 is required for cell differentiation and exhibits transcription-dependent
    dynamics@
...