---
_id: '11092'
abstract:
- lang: eng
text: To combat the functional decline of the proteome, cells use the process of
protein turnover to replace potentially impaired polypeptides with new functional
copies. We found that extremely long-lived proteins (ELLPs) did not turn over
in postmitotic cells of the rat central nervous system. These ELLPs were associated
with chromatin and the nuclear pore complex, the central transport channels that
mediate all molecular trafficking in and out of the nucleus. The longevity of
these proteins would be expected to expose them to potentially harmful metabolites,
putting them at risk of accumulating damage over extended periods of time. Thus,
it is possible that failure to maintain proper levels and functional integrity
of ELLPs in nonproliferative cells might contribute to age-related deterioration
in cell and tissue function.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Jeffrey N.
full_name: Savas, Jeffrey N.
last_name: Savas
- first_name: Brandon H.
full_name: Toyama, Brandon H.
last_name: Toyama
- first_name: Tao
full_name: Xu, Tao
last_name: Xu
- first_name: John R.
full_name: Yates, John R.
last_name: Yates
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Savas JN, Toyama BH, Xu T, Yates JR, Hetzer M. Extremely long-lived nuclear
pore proteins in the rat brain. Science. 2012;335(6071):942-942. doi:10.1126/science.1217421
apa: Savas, J. N., Toyama, B. H., Xu, T., Yates, J. R., & Hetzer, M. (2012).
Extremely long-lived nuclear pore proteins in the rat brain. Science. American
Association for the Advancement of Science. https://doi.org/10.1126/science.1217421
chicago: Savas, Jeffrey N., Brandon H. Toyama, Tao Xu, John R. Yates, and Martin
Hetzer. “Extremely Long-Lived Nuclear Pore Proteins in the Rat Brain.” Science.
American Association for the Advancement of Science, 2012. https://doi.org/10.1126/science.1217421.
ieee: J. N. Savas, B. H. Toyama, T. Xu, J. R. Yates, and M. Hetzer, “Extremely long-lived
nuclear pore proteins in the rat brain,” Science, vol. 335, no. 6071. American
Association for the Advancement of Science, pp. 942–942, 2012.
ista: Savas JN, Toyama BH, Xu T, Yates JR, Hetzer M. 2012. Extremely long-lived
nuclear pore proteins in the rat brain. Science. 335(6071), 942–942.
mla: Savas, Jeffrey N., et al. “Extremely Long-Lived Nuclear Pore Proteins in the
Rat Brain.” Science, vol. 335, no. 6071, American Association for the Advancement
of Science, 2012, pp. 942–942, doi:10.1126/science.1217421.
short: J.N. Savas, B.H. Toyama, T. Xu, J.R. Yates, M. Hetzer, Science 335 (2012)
942–942.
date_created: 2022-04-07T07:52:01Z
date_published: 2012-02-02T00:00:00Z
date_updated: 2022-07-18T08:53:06Z
day: '02'
doi: 10.1126/science.1217421
extern: '1'
external_id:
pmid:
- '22300851'
intvolume: ' 335'
issue: '6071'
keyword:
- Multidisciplinary
language:
- iso: eng
month: '02'
oa_version: None
page: 942-942
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Extremely long-lived nuclear pore proteins in the rat brain
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 335
year: '2012'
...