---
_id: '11093'
abstract:
- lang: eng
  text: Nuclear pore complexes (NPCs) are built from ∼30 different proteins called
    nucleoporins or Nups. Previous studies have shown that several Nups exhibit cell-type-specific
    expression and that mutations in NPC components result in tissue-specific diseases.
    Here we show that a specific change in NPC composition is required for both myogenic
    and neuronal differentiation. The transmembrane nucleoporin Nup210 is absent in
    proliferating myoblasts and embryonic stem cells (ESCs) but becomes expressed
    and incorporated into NPCs during cell differentiation. Preventing Nup210 production
    by RNAi blocks myogenesis and the differentiation of ESCs into neuroprogenitors.
    We found that the addition of Nup210 to NPCs does not affect nuclear transport
    but is required for the induction of genes that are essential for cell differentiation.
    Our results identify a single change in NPC composition as an essential step in
    cell differentiation and establish a role for Nup210 in gene expression regulation
    and cell fate determination.
article_processing_charge: No
article_type: original
author:
- first_name: Maximiliano A.
  full_name: D'Angelo, Maximiliano A.
  last_name: D'Angelo
- first_name: J. Sebastian
  full_name: Gomez-Cavazos, J. Sebastian
  last_name: Gomez-Cavazos
- first_name: Arianna
  full_name: Mei, Arianna
  last_name: Mei
- first_name: Daniel H.
  full_name: Lackner, Daniel H.
  last_name: Lackner
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
citation:
  ama: D’Angelo MA, Gomez-Cavazos JS, Mei A, Lackner DH, Hetzer M. A change in nuclear
    pore complex composition regulates cell differentiation. <i>Developmental Cell</i>.
    2012;22(2):446-458. doi:<a href="https://doi.org/10.1016/j.devcel.2011.11.021">10.1016/j.devcel.2011.11.021</a>
  apa: D’Angelo, M. A., Gomez-Cavazos, J. S., Mei, A., Lackner, D. H., &#38; Hetzer,
    M. (2012). A change in nuclear pore complex composition regulates cell differentiation.
    <i>Developmental Cell</i>. Elsevier. <a href="https://doi.org/10.1016/j.devcel.2011.11.021">https://doi.org/10.1016/j.devcel.2011.11.021</a>
  chicago: D’Angelo, Maximiliano A., J. Sebastian Gomez-Cavazos, Arianna Mei, Daniel H.
    Lackner, and Martin Hetzer. “A Change in Nuclear Pore Complex Composition Regulates
    Cell Differentiation.” <i>Developmental Cell</i>. Elsevier, 2012. <a href="https://doi.org/10.1016/j.devcel.2011.11.021">https://doi.org/10.1016/j.devcel.2011.11.021</a>.
  ieee: M. A. D’Angelo, J. S. Gomez-Cavazos, A. Mei, D. H. Lackner, and M. Hetzer,
    “A change in nuclear pore complex composition regulates cell differentiation,”
    <i>Developmental Cell</i>, vol. 22, no. 2. Elsevier, pp. 446–458, 2012.
  ista: D’Angelo MA, Gomez-Cavazos JS, Mei A, Lackner DH, Hetzer M. 2012. A change
    in nuclear pore complex composition regulates cell differentiation. Developmental
    Cell. 22(2), 446–458.
  mla: D’Angelo, Maximiliano A., et al. “A Change in Nuclear Pore Complex Composition
    Regulates Cell Differentiation.” <i>Developmental Cell</i>, vol. 22, no. 2, Elsevier,
    2012, pp. 446–58, doi:<a href="https://doi.org/10.1016/j.devcel.2011.11.021">10.1016/j.devcel.2011.11.021</a>.
  short: M.A. D’Angelo, J.S. Gomez-Cavazos, A. Mei, D.H. Lackner, M. Hetzer, Developmental
    Cell 22 (2012) 446–458.
date_created: 2022-04-07T07:52:10Z
date_published: 2012-01-19T00:00:00Z
date_updated: 2024-10-14T11:26:00Z
day: '19'
doi: 10.1016/j.devcel.2011.11.021
extern: '1'
external_id:
  pmid:
  - '22264802'
intvolume: '        22'
issue: '2'
keyword:
- Developmental Biology
- Cell Biology
- General Biochemistry
- Genetics and Molecular Biology
- Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.devcel.2011.11.021
month: '01'
oa: 1
oa_version: Published Version
page: 446-458
pmid: 1
publication: Developmental Cell
publication_identifier:
  issn:
  - 1534-5807
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: A change in nuclear pore complex composition regulates cell differentiation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 22
year: '2012'
...