---
_id: '11102'
abstract:
- lang: eng
  text: Nuclear pore complexes have recently been shown to play roles in gene activation;
    however their potential involvement in metazoan transcription remains unclear.
    Here we show that the nucleoporins Sec13, Nup98, and Nup88, as well as a group
    of FG-repeat nucleoporins, bind to the Drosophila genome at functionally distinct
    loci that often do not represent nuclear envelope contact sites. Whereas Nup88
    localizes to silent loci, Sec13, Nup98, and a subset of FG-repeat nucleoporins
    bind to developmentally regulated genes undergoing transcription induction. Strikingly,
    RNAi-mediated knockdown of intranuclear Sec13 and Nup98 specifically inhibits
    transcription of their target genes and prevents efficient reactivation of transcription
    after heat shock, suggesting an essential role of NPC components in regulating
    complex gene expression programs of multicellular organisms.
article_processing_charge: No
article_type: original
author:
- first_name: Maya
  full_name: Capelson, Maya
  last_name: Capelson
- first_name: Yun
  full_name: Liang, Yun
  last_name: Liang
- first_name: Roberta
  full_name: Schulte, Roberta
  last_name: Schulte
- first_name: William
  full_name: Mair, William
  last_name: Mair
- first_name: Ulrich
  full_name: Wagner, Ulrich
  last_name: Wagner
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
citation:
  ama: Capelson M, Liang Y, Schulte R, Mair W, Wagner U, Hetzer M. Chromatin-bound
    nuclear pore components regulate gene expression in higher eukaryotes. <i>Cell</i>.
    2010;140(3):372-383. doi:<a href="https://doi.org/10.1016/j.cell.2009.12.054">10.1016/j.cell.2009.12.054</a>
  apa: Capelson, M., Liang, Y., Schulte, R., Mair, W., Wagner, U., &#38; Hetzer, M.
    (2010). Chromatin-bound nuclear pore components regulate gene expression in higher
    eukaryotes. <i>Cell</i>. Elsevier. <a href="https://doi.org/10.1016/j.cell.2009.12.054">https://doi.org/10.1016/j.cell.2009.12.054</a>
  chicago: Capelson, Maya, Yun Liang, Roberta Schulte, William Mair, Ulrich Wagner,
    and Martin Hetzer. “Chromatin-Bound Nuclear Pore Components Regulate Gene Expression
    in Higher Eukaryotes.” <i>Cell</i>. Elsevier, 2010. <a href="https://doi.org/10.1016/j.cell.2009.12.054">https://doi.org/10.1016/j.cell.2009.12.054</a>.
  ieee: M. Capelson, Y. Liang, R. Schulte, W. Mair, U. Wagner, and M. Hetzer, “Chromatin-bound
    nuclear pore components regulate gene expression in higher eukaryotes,” <i>Cell</i>,
    vol. 140, no. 3. Elsevier, pp. 372–383, 2010.
  ista: Capelson M, Liang Y, Schulte R, Mair W, Wagner U, Hetzer M. 2010. Chromatin-bound
    nuclear pore components regulate gene expression in higher eukaryotes. Cell. 140(3),
    372–383.
  mla: Capelson, Maya, et al. “Chromatin-Bound Nuclear Pore Components Regulate Gene
    Expression in Higher Eukaryotes.” <i>Cell</i>, vol. 140, no. 3, Elsevier, 2010,
    pp. 372–83, doi:<a href="https://doi.org/10.1016/j.cell.2009.12.054">10.1016/j.cell.2009.12.054</a>.
  short: M. Capelson, Y. Liang, R. Schulte, W. Mair, U. Wagner, M. Hetzer, Cell 140
    (2010) 372–383.
date_created: 2022-04-07T07:53:36Z
date_published: 2010-02-05T00:00:00Z
date_updated: 2024-10-14T11:28:14Z
day: '05'
doi: 10.1016/j.cell.2009.12.054
extern: '1'
external_id:
  pmid:
  - '20144761'
intvolume: '       140'
issue: '3'
keyword:
- General Biochemistry
- Genetics and Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.cell.2009.12.054
month: '02'
oa: 1
oa_version: Published Version
page: 372-383
pmid: 1
publication: Cell
publication_identifier:
  issn:
  - 0092-8674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Chromatin-bound nuclear pore components regulate gene expression in higher
  eukaryotes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 140
year: '2010'
...