---
_id: '11108'
abstract:
- lang: eng
  text: In dividing cells, nuclear pore complexes (NPCs) disassemble during mitosis
    and reassemble into the newly forming nuclei. However, the fate of nuclear pores
    in postmitotic cells is unknown. Here, we show that NPCs, unlike other nuclear
    structures, do not turn over in differentiated cells. While a subset of NPC components,
    like Nup153 and Nup50, are continuously exchanged, scaffold nucleoporins, like
    the Nup107/160 complex, are extremely long-lived and remain incorporated in the
    nuclear membrane during the entire cellular life span. Besides the lack of nucleoporin
    expression and NPC turnover, we discovered an age-related deterioration of NPCs,
    leading to an increase in nuclear permeability and the leaking of cytoplasmic
    proteins into the nucleus. Our finding that nuclear “leakiness” is dramatically
    accelerated during aging and that a subset of nucleoporins is oxidatively damaged
    in old cells suggests that the accumulation of damage at the NPC might be a crucial
    aging event.
article_processing_charge: No
article_type: original
author:
- first_name: Maximiliano A.
  full_name: D'Angelo, Maximiliano A.
  last_name: D'Angelo
- first_name: Marcela
  full_name: Raices, Marcela
  last_name: Raices
- first_name: Siler H.
  full_name: Panowski, Siler H.
  last_name: Panowski
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
citation:
  ama: D’Angelo MA, Raices M, Panowski SH, Hetzer M. Age-dependent deterioration of
    nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells.
    <i>Cell</i>. 2009;136(2):284-295. doi:<a href="https://doi.org/10.1016/j.cell.2008.11.037">10.1016/j.cell.2008.11.037</a>
  apa: D’Angelo, M. A., Raices, M., Panowski, S. H., &#38; Hetzer, M. (2009). Age-dependent
    deterioration of nuclear pore complexes causes a loss of nuclear integrity in
    postmitotic cells. <i>Cell</i>. Elsevier. <a href="https://doi.org/10.1016/j.cell.2008.11.037">https://doi.org/10.1016/j.cell.2008.11.037</a>
  chicago: D’Angelo, Maximiliano A., Marcela Raices, Siler H. Panowski, and Martin
    Hetzer. “Age-Dependent Deterioration of Nuclear Pore Complexes Causes a Loss of
    Nuclear Integrity in Postmitotic Cells.” <i>Cell</i>. Elsevier, 2009. <a href="https://doi.org/10.1016/j.cell.2008.11.037">https://doi.org/10.1016/j.cell.2008.11.037</a>.
  ieee: M. A. D’Angelo, M. Raices, S. H. Panowski, and M. Hetzer, “Age-dependent deterioration
    of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells,”
    <i>Cell</i>, vol. 136, no. 2. Elsevier, pp. 284–295, 2009.
  ista: D’Angelo MA, Raices M, Panowski SH, Hetzer M. 2009. Age-dependent deterioration
    of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells.
    Cell. 136(2), 284–295.
  mla: D’Angelo, Maximiliano A., et al. “Age-Dependent Deterioration of Nuclear Pore
    Complexes Causes a Loss of Nuclear Integrity in Postmitotic Cells.” <i>Cell</i>,
    vol. 136, no. 2, Elsevier, 2009, pp. 284–95, doi:<a href="https://doi.org/10.1016/j.cell.2008.11.037">10.1016/j.cell.2008.11.037</a>.
  short: M.A. D’Angelo, M. Raices, S.H. Panowski, M. Hetzer, Cell 136 (2009) 284–295.
date_created: 2022-04-07T07:54:52Z
date_published: 2009-01-23T00:00:00Z
date_updated: 2024-10-14T11:28:59Z
day: '23'
doi: 10.1016/j.cell.2008.11.037
extern: '1'
external_id:
  pmid:
  - '19167330'
intvolume: '       136'
issue: '2'
keyword:
- General Biochemistry
- Genetics and Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.cell.2008.11.037
month: '01'
oa: 1
oa_version: Published Version
page: 284-295
pmid: 1
publication: Cell
publication_identifier:
  issn:
  - 0092-8674
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear
  integrity in postmitotic cells
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 136
year: '2009'
...