---
_id: '11113'
abstract:
- lang: eng
  text: The nuclear envelope (NE), a double membrane enclosing the nucleus of eukaryotic
    cells, controls the flow of information between the nucleoplasm and the cytoplasm
    and provides a scaffold for the organization of chromatin and the cytoskeleton.
    In dividing metazoan cells, the NE breaks down at the onset of mitosis and then
    reforms around segregated chromosomes to generate the daughter nuclei. Recent
    data from intact cells and cell-free nuclear assembly systems suggest that the
    endoplasmic reticulum (ER) is the source of membrane for NE assembly. At the end
    of mitosis, ER membrane tubules are targeted to chromatin via tubule ends and
    reorganized into flat nuclear membrane sheets by specific DNA-binding membrane
    proteins. In contrast to previous models, which proposed vesicle fusion to be
    the principal mechanism of NE formation, these new studies suggest that the nuclear
    membrane forms by the chromatin-mediated reshaping of the ER.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Daniel J.
  full_name: Anderson, Daniel J.
  last_name: Anderson
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
citation:
  ama: Anderson DJ, Hetzer M. Shaping the endoplasmic reticulum into the nuclear envelope.
    <i>Journal of Cell Science</i>. 2008;121(2):137-142. doi:<a href="https://doi.org/10.1242/jcs.005777">10.1242/jcs.005777</a>
  apa: Anderson, D. J., &#38; Hetzer, M. (2008). Shaping the endoplasmic reticulum
    into the nuclear envelope. <i>Journal of Cell Science</i>. The Company of Biologists.
    <a href="https://doi.org/10.1242/jcs.005777">https://doi.org/10.1242/jcs.005777</a>
  chicago: Anderson, Daniel J., and Martin Hetzer. “Shaping the Endoplasmic Reticulum
    into the Nuclear Envelope.” <i>Journal of Cell Science</i>. The Company of Biologists,
    2008. <a href="https://doi.org/10.1242/jcs.005777">https://doi.org/10.1242/jcs.005777</a>.
  ieee: D. J. Anderson and M. Hetzer, “Shaping the endoplasmic reticulum into the
    nuclear envelope,” <i>Journal of Cell Science</i>, vol. 121, no. 2. The Company
    of Biologists, pp. 137–142, 2008.
  ista: Anderson DJ, Hetzer M. 2008. Shaping the endoplasmic reticulum into the nuclear
    envelope. Journal of Cell Science. 121(2), 137–142.
  mla: Anderson, Daniel J., and Martin Hetzer. “Shaping the Endoplasmic Reticulum
    into the Nuclear Envelope.” <i>Journal of Cell Science</i>, vol. 121, no. 2, The
    Company of Biologists, 2008, pp. 137–42, doi:<a href="https://doi.org/10.1242/jcs.005777">10.1242/jcs.005777</a>.
  short: D.J. Anderson, M. Hetzer, Journal of Cell Science 121 (2008) 137–142.
date_created: 2022-04-07T07:55:46Z
date_published: 2008-01-15T00:00:00Z
date_updated: 2024-10-14T11:29:47Z
day: '15'
doi: 10.1242/jcs.005777
extern: '1'
external_id:
  pmid:
  - '18187447'
intvolume: '       121'
issue: '2'
keyword:
- Cell Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1242/jcs.005777
month: '01'
oa: 1
oa_version: Published Version
page: 137-142
pmid: 1
publication: Journal of Cell Science
publication_identifier:
  eissn:
  - 1477-9137
  issn:
  - 0021-9533
publication_status: published
publisher: The Company of Biologists
quality_controlled: '1'
scopus_import: '1'
status: public
title: Shaping the endoplasmic reticulum into the nuclear envelope
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 121
year: '2008'
...