@article{11125,
  abstract     = {Although nuclear envelope (NE) assembly is known to require the GTPase Ran, the membrane fusion machinery involved is uncharacterized. NE assembly involves formation of a reticular network on chromatin, fusion of this network into a closed NE and subsequent expansion. Here we show that p97, an AAA-ATPase previously implicated in fusion of Golgi and transitional endoplasmic reticulum (ER) membranes together with the adaptor p47, has two discrete functions in NE assembly. Formation of a closed NE requires the p97–Ufd1–Npl4 complex, not previously implicated in membrane fusion. Subsequent NE growth involves a p97–p47 complex. This study provides the first insights into the molecular mechanisms and specificity of fusion events involved in NE formation.},
  author       = {HETZER, Martin W and Meyer, Hemmo H. and Walther, Tobias C. and Bilbao-Cortes, Daniel and Warren, Graham and Mattaj, Iain W.},
  issn         = {1476-4679},
  journal      = {Nature Cell Biology},
  keywords     = {Cell Biology},
  number       = {12},
  pages        = {1086--1091},
  publisher    = {Springer Nature},
  title        = {{Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly}},
  doi          = {10.1038/ncb1201-1086},
  volume       = {3},
  year         = {2001},
}