{"day":"01","intvolume":"        74","language":[{"iso":"eng"}],"date_created":"2022-04-15T09:32:35Z","publication_identifier":{"issn":["0959-440X"]},"file_date_updated":"2022-08-05T05:56:03Z","title":"Structure of respiratory complex I – An emerging blueprint for the mechanism","article_processing_charge":"Yes (via OA deal)","department":[{"_id":"LeSa"}],"oa_version":"Published Version","date_published":"2022-06-01T00:00:00Z","pmid":1,"abstract":[{"lang":"eng","text":"Complex I is one of the major respiratory complexes, conserved from bacteria to mammals. It oxidises NADH, reduces quinone and pumps protons across the membrane, thus playing a central role in the oxidative energy metabolism. In this review we discuss our current state of understanding the structure of complex I from various species of mammals, plants, fungi, and bacteria, as well as of several complex I-related proteins. By comparing the structural evidence from these systems in different redox states and data from mutagenesis and molecular simulations, we formulate the mechanisms of electron transfer and proton pumping and explain how they are conformationally and electrostatically coupled. Finally, we discuss the structural basis of the deactivation phenomenon in mammalian complex I."}],"oa":1,"type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publisher":"Elsevier","article_type":"original","article_number":"102350","file":[{"file_id":"11725","success":1,"access_level":"open_access","creator":"dernst","checksum":"72bdde48853643a32d42b75f54965c44","date_updated":"2022-08-05T05:56:03Z","date_created":"2022-08-05T05:56:03Z","file_size":815607,"content_type":"application/pdf","file_name":"2022_CurrentOpStructBiology_Kampjut.pdf","relation":"main_file"}],"_id":"11167","year":"2022","doi":"10.1016/j.sbi.2022.102350","quality_controlled":"1","date_updated":"2023-08-03T06:31:06Z","has_accepted_license":"1","author":[{"full_name":"Kampjut, Domen","first_name":"Domen","last_name":"Kampjut","id":"37233050-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Sazanov, Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0977-7989","last_name":"Sazanov","first_name":"Leonid A"}],"external_id":{"pmid":["35316665"],"isi":["000829029500020"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","status":"public","publication_status":"published","isi":1,"citation":{"ieee":"D. Kampjut and L. A. Sazanov, “Structure of respiratory complex I – An emerging blueprint for the mechanism,” <i>Current Opinion in Structural Biology</i>, vol. 74. Elsevier, 2022.","short":"D. Kampjut, L.A. Sazanov, Current Opinion in Structural Biology 74 (2022).","apa":"Kampjut, D., &#38; Sazanov, L. A. (2022). Structure of respiratory complex I – An emerging blueprint for the mechanism. <i>Current Opinion in Structural Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.sbi.2022.102350\">https://doi.org/10.1016/j.sbi.2022.102350</a>","chicago":"Kampjut, Domen, and Leonid A Sazanov. “Structure of Respiratory Complex I – An Emerging Blueprint for the Mechanism.” <i>Current Opinion in Structural Biology</i>. Elsevier, 2022. <a href=\"https://doi.org/10.1016/j.sbi.2022.102350\">https://doi.org/10.1016/j.sbi.2022.102350</a>.","ama":"Kampjut D, Sazanov LA. Structure of respiratory complex I – An emerging blueprint for the mechanism. <i>Current Opinion in Structural Biology</i>. 2022;74. doi:<a href=\"https://doi.org/10.1016/j.sbi.2022.102350\">10.1016/j.sbi.2022.102350</a>","mla":"Kampjut, Domen, and Leonid A. Sazanov. “Structure of Respiratory Complex I – An Emerging Blueprint for the Mechanism.” <i>Current Opinion in Structural Biology</i>, vol. 74, 102350, Elsevier, 2022, doi:<a href=\"https://doi.org/10.1016/j.sbi.2022.102350\">10.1016/j.sbi.2022.102350</a>.","ista":"Kampjut D, Sazanov LA. 2022. Structure of respiratory complex I – An emerging blueprint for the mechanism. Current Opinion in Structural Biology. 74, 102350."},"publication":"Current Opinion in Structural Biology","month":"06","keyword":["Molecular Biology","Structural Biology"],"scopus_import":"1","volume":74,"ddc":["570"]}