---
_id: '1118'
abstract:
- lang: eng
  text: Sharp wave-ripple (SWR) oscillations play a key role in memory consolidation
    during non-rapid eye movement sleep, immobility, and consummatory behavior. However,
    whether temporally modulated synaptic excitation or inhibition underlies the ripples
    is controversial. To address this question, we performed simultaneous recordings
    of excitatory and inhibitory postsynaptic currents (EPSCs and IPSCs) and local
    field potentials (LFPs) in the CA1 region of awake mice in vivo. During SWRs,
    inhibition dominated over excitation, with a peak conductance ratio of 4.1 ± 0.5.
    Furthermore, the amplitude of SWR-associated IPSCs was positively correlated with
    SWR magnitude, whereas that of EPSCs was not. Finally, phase analysis indicated
    that IPSCs were phase-locked to individual ripple cycles, whereas EPSCs were uniformly
    distributed in phase space. Optogenetic inhibition indicated that PV+ interneurons
    provided a major contribution to SWR-associated IPSCs. Thus, phasic inhibition,
    but not excitation, shapes SWR oscillations in the hippocampal CA1 region in vivo.
acknowledged_ssus:
- _id: M-Shop
- _id: ScienComp
- _id: PreCl
article_processing_charge: No
author:
- first_name: Jian
  full_name: Gan, Jian
  id: 3614E438-F248-11E8-B48F-1D18A9856A87
  last_name: Gan
- first_name: Shih-Ming
  full_name: Weng, Shih-Ming
  id: 2F9C5AC8-F248-11E8-B48F-1D18A9856A87
  last_name: Weng
- first_name: Alejandro
  full_name: Pernia-Andrade, Alejandro
  id: 36963E98-F248-11E8-B48F-1D18A9856A87
  last_name: Pernia-Andrade
- first_name: Jozsef L
  full_name: Csicsvari, Jozsef L
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Gan J, Weng S-M, Pernia-Andrade A, Csicsvari JL, Jonas PM. Phase-locked inhibition,
    but not excitation, underlies hippocampal ripple oscillations in awake mice in
    vivo. <i>Neuron</i>. 2017;93(2):308-314. doi:<a href="https://doi.org/10.1016/j.neuron.2016.12.018">10.1016/j.neuron.2016.12.018</a>
  apa: Gan, J., Weng, S.-M., Pernia-Andrade, A., Csicsvari, J. L., &#38; Jonas, P.
    M. (2017). Phase-locked inhibition, but not excitation, underlies hippocampal
    ripple oscillations in awake mice in vivo. <i>Neuron</i>. Elsevier. <a href="https://doi.org/10.1016/j.neuron.2016.12.018">https://doi.org/10.1016/j.neuron.2016.12.018</a>
  chicago: Gan, Jian, Shih-Ming Weng, Alejandro Pernia-Andrade, Jozsef L Csicsvari,
    and Peter M Jonas. “Phase-Locked Inhibition, but Not Excitation, Underlies Hippocampal
    Ripple Oscillations in Awake Mice in Vivo.” <i>Neuron</i>. Elsevier, 2017. <a
    href="https://doi.org/10.1016/j.neuron.2016.12.018">https://doi.org/10.1016/j.neuron.2016.12.018</a>.
  ieee: J. Gan, S.-M. Weng, A. Pernia-Andrade, J. L. Csicsvari, and P. M. Jonas, “Phase-locked
    inhibition, but not excitation, underlies hippocampal ripple oscillations in awake
    mice in vivo,” <i>Neuron</i>, vol. 93, no. 2. Elsevier, pp. 308–314, 2017.
  ista: Gan J, Weng S-M, Pernia-Andrade A, Csicsvari JL, Jonas PM. 2017. Phase-locked
    inhibition, but not excitation, underlies hippocampal ripple oscillations in awake
    mice in vivo. Neuron. 93(2), 308–314.
  mla: Gan, Jian, et al. “Phase-Locked Inhibition, but Not Excitation, Underlies Hippocampal
    Ripple Oscillations in Awake Mice in Vivo.” <i>Neuron</i>, vol. 93, no. 2, Elsevier,
    2017, pp. 308–14, doi:<a href="https://doi.org/10.1016/j.neuron.2016.12.018">10.1016/j.neuron.2016.12.018</a>.
  short: J. Gan, S.-M. Weng, A. Pernia-Andrade, J.L. Csicsvari, P.M. Jonas, Neuron
    93 (2017) 308–314.
date_created: 2018-12-11T11:50:15Z
date_published: 2017-01-18T00:00:00Z
date_updated: 2025-04-15T07:20:01Z
day: '18'
ddc:
- '571'
department:
- _id: PeJo
- _id: JoCs
doi: 10.1016/j.neuron.2016.12.018
ec_funded: 1
external_id:
  isi:
  - '000396428200010'
file:
- access_level: open_access
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:08:56Z
  date_updated: 2018-12-12T10:08:56Z
  file_id: '4719'
  file_name: IST-2017-752-v1+1_1-s2.0-S0896627316309606-main.pdf
  file_size: 2738950
  relation: main_file
file_date_updated: 2018-12-12T10:08:56Z
has_accepted_license: '1'
intvolume: '        93'
isi: 1
issue: '2'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 308 - 314
project:
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P24909-B24
  name: Mechanisms of transmitter release at GABAergic synapses
- _id: 25C0F108-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '268548'
  name: Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons
publication: Neuron
publication_status: published
publisher: Elsevier
publist_id: '6244'
pubrep_id: '752'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Phase-locked inhibition, but not excitation, underlies hippocampal ripple oscillations
  in awake mice in vivo
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 93
year: '2017'
...