{"article_processing_charge":"No","author":[{"id":"34DA8BD6-F248-11E8-B48F-1D18A9856A87","last_name":"Rieckh","full_name":"Rieckh, Georg","first_name":"Georg"}],"day":"01","_id":"1128","file_date_updated":"2020-09-21T11:30:40Z","oa":1,"file":[{"creator":"dernst","relation":"main_file","date_updated":"2019-08-13T11:46:25Z","access_level":"closed","file_name":"Thesis_Georg_Rieckh_w_signature_page.pdf","file_id":"6815","checksum":"ec453918c3bf8e6f460fd1156ef7b493","date_created":"2019-08-13T11:46:25Z","content_type":"application/pdf","file_size":2614660},{"file_size":6096178,"file_id":"8542","success":1,"content_type":"application/pdf","date_created":"2020-09-21T11:30:40Z","checksum":"51ae398166370d18fd22478b6365c4da","date_updated":"2020-09-21T11:30:40Z","access_level":"open_access","file_name":"Thesis_Georg_Rieckh.pdf","creator":"dernst","relation":"main_file"}],"alternative_title":["ISTA Thesis"],"citation":{"mla":"Rieckh, Georg. <i>Studying the Complexities of Transcriptional Regulation</i>. Institute of Science and Technology Austria, 2016.","ieee":"G. Rieckh, “Studying the complexities of transcriptional regulation,” Institute of Science and Technology Austria, 2016.","ista":"Rieckh G. 2016. Studying the complexities of transcriptional regulation. Institute of Science and Technology Austria.","ama":"Rieckh G. Studying the complexities of transcriptional regulation. 2016.","apa":"Rieckh, G. (2016). <i>Studying the complexities of transcriptional regulation</i>. Institute of Science and Technology Austria.","short":"G. Rieckh, Studying the Complexities of Transcriptional Regulation, Institute of Science and Technology Austria, 2016.","chicago":"Rieckh, Georg. “Studying the Complexities of Transcriptional Regulation.” Institute of Science and Technology Austria, 2016."},"page":"114","ddc":["570"],"publist_id":"6232","type":"dissertation","department":[{"_id":"GaTk"}],"supervisor":[{"first_name":"Gasper","full_name":"Tkacik, Gasper","last_name":"Tkacik","orcid":"0000-0002-6699-1455","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87"}],"status":"public","degree_awarded":"PhD","has_accepted_license":"1","publication_status":"published","title":"Studying the complexities of transcriptional regulation","publisher":"Institute of Science and Technology Austria","abstract":[{"lang":"eng","text":"The process of gene expression is central to the modern understanding of how cellular systems\r\nfunction. In this process, a special kind of regulatory proteins, called transcription factors,\r\nare important to determine how much protein is produced from a given gene. As biological\r\ninformation is transmitted from transcription factor concentration to mRNA levels to amounts of\r\nprotein, various sources of noise arise and pose limits to the fidelity of intracellular signaling.\r\nThis thesis concerns itself with several aspects of stochastic gene expression: (i) the mathematical\r\ndescription of complex promoters responsible for the stochastic production of biomolecules,\r\n(ii) fundamental limits to information processing the cell faces due to the interference from multiple\r\nfluctuating signals, (iii) how the presence of gene expression noise influences the evolution\r\nof regulatory sequences, (iv) and tools for the experimental study of origins and consequences\r\nof cell-cell heterogeneity, including an application to bacterial stress response systems."}],"date_updated":"2023-09-07T11:44:34Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_created":"2018-12-11T11:50:18Z","language":[{"iso":"eng"}],"date_published":"2016-08-01T00:00:00Z","year":"2016","oa_version":"Published Version","publication_identifier":{"issn":["2663-337X"]},"month":"08"}