---
res:
  bibo_abstract:
  - Until recently, Shigella and enteroinvasive Escherichia coli were thought to be
    primate-restricted pathogens. The base of their pathogenicity is the type 3 secretion
    system (T3SS) encoded by the pINV virulence plasmid, which facilitates host cell
    invasion and subsequent proliferation. A large family of T3SS effectors, E3 ubiquitin-ligases
    encoded by the ipaH genes, have a key role in the Shigella pathogenicity through
    the modulation of cellular ubiquitination that degrades host proteins. However,
    recent genomic studies identified ipaH genes in the genomes of Escherichia marmotae,
    a potential marmot pathogen, and an E. coli extracted from fecal samples of bovine
    calves, suggesting that non-human hosts may also be infected by these strains,
    potentially pathogenic to humans. We performed a comparative genomic study of
    the functional repertoires in the ipaH gene family in Shigella and enteroinvasive
    Escherichia from human and predicted non-human hosts. We found that fewer than
    half of Shigella genomes had a complete set of ipaH genes, with frequent gene
    losses and duplications that were not consistent with the species tree and nomenclature.
    Non-human host IpaH proteins had a diverse set of substrate-binding domains and,
    in contrast to the Shigella proteins, two variants of the NEL C-terminal domain.
    Inconsistencies between strains phylogeny and composition of effectors indicate
    horizontal gene transfer between E. coli adapted to different hosts. These results
    provide a framework for understanding of ipaH-mediated host-pathogens interactions
    and suggest a need for a genomic study of fecal samples from diseased animals.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: NO
      foaf_name: Dranenko, NO
      foaf_surname: Dranenko
  - foaf_Person:
      foaf_givenName: MN
      foaf_name: Tutukina, MN
      foaf_surname: Tutukina
  - foaf_Person:
      foaf_givenName: MS
      foaf_name: Gelfand, MS
      foaf_surname: Gelfand
  - foaf_Person:
      foaf_givenName: Fyodor
      foaf_name: Kondrashov, Fyodor
      foaf_surname: Kondrashov
      foaf_workInfoHomepage: http://www.librecat.org/personId=44FDEF62-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8243-4694
  - foaf_Person:
      foaf_givenName: Olga
      foaf_name: Bochkareva, Olga
      foaf_surname: Bochkareva
      foaf_workInfoHomepage: http://www.librecat.org/personId=C4558D3C-6102-11E9-A62E-F418E6697425
    orcid: 0000-0003-1006-6639
  bibo_doi: 10.1038/s41598-022-10827-3
  bibo_volume: 12
  dct_date: 2022^xs_gYear
  dct_identifier:
  - UT:000788639400032
  dct_isPartOf:
  - http://id.crossref.org/issn/2045-2322
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Chromosome-encoded IpaH ubiquitin ligases indicate non-human enteroinvasive
    Escherichia@
  fabio_hasPubmedId: '35477739'
...