---
res:
  bibo_abstract:
  - Empirical essays of fitness landscapes suggest that they may be rugged, that is
    having multiple fitness peaks. Such fitness landscapes, those that have multiple
    peaks, necessarily have special local structures, called reciprocal sign epistasis
    (Poelwijk et al. in J Theor Biol 272:141–144, 2011). Here, we investigate the
    quantitative relationship between the number of fitness peaks and the number of
    reciprocal sign epistatic interactions. Previously, it has been shown (Poelwijk
    et al. in J Theor Biol 272:141–144, 2011) that pairwise reciprocal sign epistasis
    is a necessary but not sufficient condition for the existence of multiple peaks.
    Applying discrete Morse theory, which to our knowledge has never been used in
    this context, we extend this result by giving the minimal number of reciprocal
    sign epistatic interactions required to create a given number of peaks.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Raimundo J
      foaf_name: Saona Urmeneta, Raimundo J
      foaf_surname: Saona Urmeneta
      foaf_workInfoHomepage: http://www.librecat.org/personId=BD1DF4C4-D767-11E9-B658-BC13E6697425
    orcid: 0000-0001-5103-038X
  - foaf_Person:
      foaf_givenName: Fyodor
      foaf_name: Kondrashov, Fyodor
      foaf_surname: Kondrashov
      foaf_workInfoHomepage: http://www.librecat.org/personId=44FDEF62-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8243-4694
  - foaf_Person:
      foaf_givenName: Kseniia
      foaf_name: Khudiakova, Kseniia
      foaf_surname: Khudiakova
      foaf_workInfoHomepage: http://www.librecat.org/personId=4E6DC800-AE37-11E9-AC72-31CAE5697425
    orcid: 0000-0002-6246-1465
  bibo_doi: 10.1007/s11538-022-01029-z
  bibo_issue: '8'
  bibo_volume: 84
  dct_date: 2022^xs_gYear
  dct_identifier:
  - UT:000812509800001
  dct_isPartOf:
  - http://id.crossref.org/issn/0092-8240
  - http://id.crossref.org/issn/1522-9602
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_subject:
  - Computational Theory and Mathematics
  - General Agricultural and Biological Sciences
  - Pharmacology
  - General Environmental Science
  - General Biochemistry
  - Genetics and Molecular Biology
  - General Mathematics
  - Immunology
  - General Neuroscience
  dct_title: Relation between the number of peaks and the number of reciprocal sign
    epistatic interactions@
  fabio_hasPubmedId: '35713756'
...