---
_id: '1146'
abstract:
- lang: eng
text: 'Aim: The present study was to compare the effects of nicotinic acid and nicotinamide
on the plasma methyl donors, choline and betaine. Methods: Thirty adult subjects
were randomly divided into three groups of equal size, and orally received purified
water (C group), nicotinic acid (300 mg, NA group) or nicotinamide (300 mg, NM
group). Plasma nicotinamide, N 1-methylnicotinamide, homocysteine, betaine and
choline levels before and 1.5-h and 3-h post-dosing, plasma normetanephrine and
metanephrine concentrations at 3-h post-dosing, and the urinary excretion of N
1-methyl-2-pyridone-5-carboxamide during the test period were examined. Results:
The level of 3-h plasma nicotinamide, N 1-methylnicotinamide, homocysteine, the
urinary excretion of N 1-methyl-2-pyridone-5-carboxamide and pulse pressure (PP)
in the NM group was 221%, 3972%, 61%, 1728% and 21.2% higher than that of the
control group (P < 0.01, except homocysteine and PP P < 0.05), while the
3-h plasma betaine, normetanephrine and metanephrine level in the NM group was
24.4%, 9.4% and 11.7% lower (P < 0.05, except betaine P < 0.01), without
significant difference in choline levels. Similar but less pronounced changes
were observed in the NA group, with a lower level of 3-h plasma N 1-methylnicotinamide
(1.90 ± 0.20 μmol/l vs. 3.62 ± 0.27 μmol/l, P < 0.01) and homocysteine (12.85
± 1.39 μmol/l vs. 18.08 ± 1.02 μmol/l, P < 0.05) but a higher level of betaine
(27.44 ± 0.71 μmol/l vs. 23.52 ± 0.61 μmol/l, P < 0.05) than that of the NM
group. Conclusion: The degradation of nicotinamide consumes more betaine than
that of nicotinic acid at identical doses. This difference should be taken into
consideration in niacin fortification. © 2016 Elsevier Ltd and European Society
for Clinical Nutrition and Metabolism.'
acknowledgement: We thank all the participants for their contribution to this study
and volunteers from the Nursing School of Dalian University for their supporting
to collect blood and urine samples of the participants. We also thank Dr. Yasunori
Takayama from National Institute for Physiological Sciences of Japan for his kind
help.
article_processing_charge: No
author:
- first_name: Wuping
full_name: Sun, Wuping
last_name: Sun
- first_name: Ming-Zhu
full_name: Zhai, Ming-Zhu
id: 34009CFA-F248-11E8-B48F-1D18A9856A87
last_name: Zhai
- first_name: Da
full_name: Li, Da
last_name: Li
- first_name: Yiming
full_name: Zhou, Yiming
last_name: Zhou
- first_name: Nana
full_name: Chen, Nana
last_name: Chen
- first_name: Ming
full_name: Guo, Ming
last_name: Guo
- first_name: Shisheng
full_name: Zhou, Shisheng
last_name: Zhou
citation:
ama: Sun W, Zhai M-Z, Li D, et al. Comparison of the effects of nicotinic acid and
nicotinamide degradation on plasma betaine and choline levels. Clinical Nutrition.
2017;36(4):1136-1142. doi:10.1016/j.clnu.2016.07.016
apa: Sun, W., Zhai, M.-Z., Li, D., Zhou, Y., Chen, N., Guo, M., & Zhou, S. (2017).
Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma
betaine and choline levels. Clinical Nutrition. Elsevier. https://doi.org/10.1016/j.clnu.2016.07.016
chicago: Sun, Wuping, Ming-Zhu Zhai, Da Li, Yiming Zhou, Nana Chen, Ming Guo, and
Shisheng Zhou. “Comparison of the Effects of Nicotinic Acid and Nicotinamide Degradation
on Plasma Betaine and Choline Levels.” Clinical Nutrition. Elsevier, 2017.
https://doi.org/10.1016/j.clnu.2016.07.016.
ieee: W. Sun et al., “Comparison of the effects of nicotinic acid and nicotinamide
degradation on plasma betaine and choline levels,” Clinical Nutrition,
vol. 36, no. 4. Elsevier, pp. 1136–1142, 2017.
ista: Sun W, Zhai M-Z, Li D, Zhou Y, Chen N, Guo M, Zhou S. 2017. Comparison of
the effects of nicotinic acid and nicotinamide degradation on plasma betaine and
choline levels. Clinical Nutrition. 36(4), 1136–1142.
mla: Sun, Wuping, et al. “Comparison of the Effects of Nicotinic Acid and Nicotinamide
Degradation on Plasma Betaine and Choline Levels.” Clinical Nutrition,
vol. 36, no. 4, Elsevier, 2017, pp. 1136–42, doi:10.1016/j.clnu.2016.07.016.
short: W. Sun, M.-Z. Zhai, D. Li, Y. Zhou, N. Chen, M. Guo, S. Zhou, Clinical Nutrition
36 (2017) 1136–1142.
date_created: 2018-12-11T11:50:24Z
date_published: 2017-08-01T00:00:00Z
date_updated: 2023-10-16T11:09:39Z
day: '01'
department:
- _id: RySh
doi: 10.1016/j.clnu.2016.07.016
intvolume: ' 36'
issue: '4'
language:
- iso: eng
month: '08'
oa_version: None
page: 1136-1142
publication: Clinical Nutrition
publication_identifier:
issn:
- 0261-5614
publication_status: published
publisher: Elsevier
publist_id: '6212'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Comparison of the effects of nicotinic acid and nicotinamide degradation on
plasma betaine and choline levels
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 36
year: '2017'
...