--- res: bibo_abstract: - Tissue patterning in multicellular organisms is the output of precise spatio–temporal regulation of gene expression coupled with changes in hormone dynamics. In plants, the hormone auxin regulates growth and development at every stage of a plant’s life cycle. Auxin signaling occurs through binding of the auxin molecule to a TIR1/AFB F-box ubiquitin ligase, allowing interaction with Aux/IAA transcriptional repressor proteins. These are subsequently ubiquitinated and degraded via the 26S proteasome, leading to derepression of auxin response factors (ARFs). How auxin is able to elicit such a diverse range of developmental responses through a single signaling module has not yet been resolved. Here we present an alternative auxin-sensing mechanism in which the ARF ARF3/ETTIN controls gene expression through interactions with process-specific transcription factors. This noncanonical hormonesensing mechanism exhibits strong preference for the naturally occurring auxin indole 3-acetic acid (IAA) and is important for coordinating growth and patterning in diverse developmental contexts such as gynoecium morphogenesis, lateral root emergence, ovule development, and primary branch formation. Disrupting this IAA-sensing ability induces morphological aberrations with consequences for plant fitness. Therefore, our findings introduce a novel transcription factor-based mechanism of hormone perception in plants. © 2016 Simonini et al.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Sara foaf_name: Simonini, Sara foaf_surname: Simonini - foaf_Person: foaf_givenName: Joyita foaf_name: Deb, Joyita foaf_surname: Deb - foaf_Person: foaf_givenName: Laila foaf_name: Moubayidin, Laila foaf_surname: Moubayidin - foaf_Person: foaf_givenName: Pauline foaf_name: Stephenson, Pauline foaf_surname: Stephenson - foaf_Person: foaf_givenName: Manoj foaf_name: Valluru, Manoj foaf_surname: Valluru - foaf_Person: foaf_givenName: Alejandra foaf_name: Freire Rios, Alejandra foaf_surname: Freire Rios - foaf_Person: foaf_givenName: Karim foaf_name: Sorefan, Karim foaf_surname: Sorefan - foaf_Person: foaf_givenName: Dolf foaf_name: Weijers, Dolf foaf_surname: Weijers - foaf_Person: foaf_givenName: Jirí foaf_name: Friml, Jirí foaf_surname: Friml foaf_workInfoHomepage: http://www.librecat.org/personId=4159519E-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-8302-7596 - foaf_Person: foaf_givenName: Lars foaf_name: Östergaard, Lars foaf_surname: Östergaard bibo_doi: 10.1101/gad.285361.116 bibo_issue: '20' bibo_volume: 30 dct_date: 2016^xs_gYear dct_language: eng dct_publisher: Cold Spring Harbor Laboratory Press@ dct_title: A noncanonical auxin sensing mechanism is required for organ morphogenesis in arabidopsis@ fabio_hasPubmedId: '27898393' ...