---
res:
  bibo_abstract:
  - "Cellular locomotion is a central hallmark of eukaryotic life. It is governed
    by cell-extrinsic molecular factors, which can either emerge in the soluble phase
    or as immobilized, often adhesive ligands. To encode for direction, every cue
    must be present as a spatial or temporal gradient. Here, we developed a microfluidic
    chamber that allows measurement of cell migration in combined response to surface
    immobilized and soluble molecular gradients. As a proof of principle we study
    the response of dendritic cells to their major guidance cues, chemokines. The
    majority of data on chemokine gradient sensing is based on in vitro studies employing
    soluble gradients. Despite evidence suggesting that in vivo chemokines are often
    immobilized to sugar residues, limited information is available how cells respond
    to immobilized chemokines. We tracked migration of dendritic cells towards immobilized
    gradients of the chemokine CCL21 and varying superimposed soluble gradients of
    CCL19. Differential migratory patterns illustrate the potential of our setup to
    quantitatively study the competitive response to both types of gradients. Beyond
    chemokines our approach is broadly applicable to alternative systems of chemo-
    and haptotaxis such as cells migrating along gradients of adhesion receptor ligands
    vs. any soluble cue. \r\n@eng"
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Jan
      foaf_name: Schwarz, Jan
      foaf_surname: Schwarz
      foaf_workInfoHomepage: http://www.librecat.org/personId=346C1EC6-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Veronika
      foaf_name: Bierbaum, Veronika
      foaf_surname: Bierbaum
      foaf_workInfoHomepage: http://www.librecat.org/personId=3FD04378-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Jack
      foaf_name: Merrin, Jack
      foaf_surname: Merrin
      foaf_workInfoHomepage: http://www.librecat.org/personId=4515C308-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-5145-4609
  - foaf_Person:
      foaf_givenName: Tino
      foaf_name: Frank, Tino
      foaf_surname: Frank
  - foaf_Person:
      foaf_givenName: Robert
      foaf_name: Hauschild, Robert
      foaf_surname: Hauschild
      foaf_workInfoHomepage: http://www.librecat.org/personId=4E01D6B4-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-9843-3522
  - foaf_Person:
      foaf_givenName: Mark Tobias
      foaf_name: Bollenbach, Mark Tobias
      foaf_surname: Bollenbach
      foaf_workInfoHomepage: http://www.librecat.org/personId=3E6DB97A-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-4398-476X
  - foaf_Person:
      foaf_givenName: Savaş
      foaf_name: Tay, Savaş
      foaf_surname: Tay
  - foaf_Person:
      foaf_givenName: Michael K
      foaf_name: Sixt, Michael K
      foaf_surname: Sixt
      foaf_workInfoHomepage: http://www.librecat.org/personId=41E9FBEA-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6620-9179
  - foaf_Person:
      foaf_givenName: Matthias
      foaf_name: Mehling, Matthias
      foaf_surname: Mehling
      foaf_workInfoHomepage: http://www.librecat.org/personId=3C23B994-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8599-1226
  bibo_doi: 10.1038/srep36440
  bibo_volume: 6
  dct_date: 2016^xs_gYear
  dct_identifier:
  - UT:000387118300001
  dct_language: eng
  dct_publisher: Nature Publishing Group@
  dct_title: A microfluidic device for measuring cell migration towards substrate
    bound and soluble chemokine gradients@
...