{"oa":1,"article_type":"original","issue":"30","publication_status":"published","license":"https://creativecommons.org/licenses/by/4.0/","publication":"Proceedings of the National Academy of Sciences of the United States of America","status":"public","pmid":1,"acknowledgement":"I thank Laura Hayward, Jitka Polechova, and Anja Westram for discussions and comments.","has_accepted_license":"1","volume":119,"external_id":{"pmid":["35858408"]},"abstract":[{"lang":"eng","text":"When Mendel’s work was rediscovered in 1900, and extended to establish classical genetics, it was initially seen in opposition to Darwin’s theory of evolution by natural selection on continuous variation, as represented by the biometric research program that was the foundation of quantitative genetics. As Fisher, Haldane, and Wright established a century ago, Mendelian inheritance is exactly what is needed for natural selection to work efficiently. Yet, the synthesis remains unfinished. We do not understand why sexual reproduction and a fair meiosis predominate in eukaryotes, or how far these are responsible for their diversity and complexity. Moreover, although quantitative geneticists have long known that adaptive variation is highly polygenic, and that this is essential for efficient selection, this is only now becoming appreciated by molecular biologists—and we still do not have a good framework for understanding polygenic variation or diffuse function."}],"ddc":["570"],"citation":{"apa":"Barton, N. H. (2022). The “New Synthesis.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. Proceedings of the National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.2122147119\">https://doi.org/10.1073/pnas.2122147119</a>","ama":"Barton NH. The “New Synthesis.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 2022;119(30). doi:<a href=\"https://doi.org/10.1073/pnas.2122147119\">10.1073/pnas.2122147119</a>","short":"N.H. Barton, Proceedings of the National Academy of Sciences of the United States of America 119 (2022).","mla":"Barton, Nicholas H. “The ‘New Synthesis.’” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 119, no. 30, e2122147119, Proceedings of the National Academy of Sciences, 2022, doi:<a href=\"https://doi.org/10.1073/pnas.2122147119\">10.1073/pnas.2122147119</a>.","chicago":"Barton, Nicholas H. “The ‘New Synthesis.’” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. Proceedings of the National Academy of Sciences, 2022. <a href=\"https://doi.org/10.1073/pnas.2122147119\">https://doi.org/10.1073/pnas.2122147119</a>.","ista":"Barton NH. 2022. The ‘New Synthesis’. Proceedings of the National Academy of Sciences of the United States of America. 119(30), e2122147119.","ieee":"N. H. Barton, “The ‘New Synthesis,’” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 119, no. 30. Proceedings of the National Academy of Sciences, 2022."},"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"checksum":"06c866196a8957f0c37b8a121771c885","relation":"main_file","file_id":"11716","success":1,"date_created":"2022-08-01T10:58:28Z","file_size":848511,"date_updated":"2022-08-01T10:58:28Z","file_name":"2022_PNAS_Barton.pdf","creator":"dernst","content_type":"application/pdf","access_level":"open_access"}],"author":[{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","full_name":"Barton, Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"NiBa"}],"language":[{"iso":"eng"}],"title":"The \"New Synthesis\"","publication_identifier":{"issn":["0027-8424"],"eissn":["1091-6490"]},"file_date_updated":"2022-08-01T10:58:28Z","year":"2022","type":"journal_article","day":"18","oa_version":"Published Version","date_updated":"2022-08-01T11:00:25Z","quality_controlled":"1","scopus_import":"1","publisher":"Proceedings of the National Academy of Sciences","_id":"11702","date_published":"2022-07-18T00:00:00Z","date_created":"2022-07-31T22:01:47Z","doi":"10.1073/pnas.2122147119","article_processing_charge":"No","month":"07","article_number":"e2122147119","intvolume":"       119"}