---
res:
  bibo_abstract:
  - The genetic analysis of experimentally evolving populations typically relies on
    short reads from pooled individuals (Pool-Seq). While this method provides reliable
    allele frequency estimates, the underlying haplotype structure remains poorly
    characterized. With small population sizes and adaptive variants that start from
    low frequencies, the interpretation of selection signatures in most Evolve and
    Resequencing studies remains challenging. To facilitate the characterization of
    selection targets, we propose a new approach that reconstructs selected haplotypes
    from replicated time series, using Pool-Seq data. We identify selected haplotypes
    through the correlated frequencies of alleles carried by them. Computer simulations
    indicate that selected haplotype-blocks of several Mb can be reconstructed with
    high confidence and low error rates, even when allele frequencies change only
    by 20% across three replicates. Applying this method to real data from D. melanogaster
    populations adapting to a hot environment, we identify a selected haplotype-block
    of 6.93 Mb. We confirm the presence of this haplotype-block in evolved populations
    by experimental haplotyping, demonstrating the power and accuracy of our haplotype
    reconstruction from Pool-Seq data. We propose that the combination of allele frequency
    estimates with haplotype information will provide the key to understanding the
    dynamics of adaptive alleles. @eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Susan
      foaf_name: Franssen, Susan
      foaf_surname: Franssen
  - foaf_Person:
      foaf_givenName: Nicholas H
      foaf_name: Barton, Nicholas H
      foaf_surname: Barton
      foaf_workInfoHomepage: http://www.librecat.org/personId=4880FE40-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8548-5240
  - foaf_Person:
      foaf_givenName: Christian
      foaf_name: Schlötterer, Christian
      foaf_surname: Schlötterer
  bibo_doi: 10.1093/molbev/msw210
  bibo_issue: '1'
  bibo_volume: 34
  dct_date: 2016^xs_gYear
  dct_identifier:
  - UT:000396772000009
  dct_language: eng
  dct_publisher: Oxford University Press@
  dct_title: Reconstruction of haplotype-blocks selected during experimental evolution.@
...