{"intvolume":"        18","quality_controlled":"1","language":[{"iso":"eng"}],"page":"5047-5055","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2012-04-16T00:00:00Z","publication":"Chemistry – A European Journal","day":"16","publication_status":"published","external_id":{"pmid":["22396386"]},"doi":"10.1002/chem.201103748","pmid":1,"author":[{"last_name":"Pieber","full_name":"Pieber, Bartholomäus","id":"93e5e5b2-0da6-11ed-8a41-af589a024726","orcid":"0000-0001-8689-388X","first_name":"Bartholomäus"},{"first_name":"David","full_name":"Cantillo, David","last_name":"Cantillo"},{"first_name":"C. Oliver","full_name":"Kappe, C. Oliver","last_name":"Kappe"}],"volume":18,"_id":"11964","year":"2012","abstract":[{"text":"A detailed investigation on the direct arylation of benzene with aryl bromides by using first-row transition metals under high-temperature/high-pressure (high-T/p) conditions is described. By employing a parallel reactor platform for rapid reaction screening and discovery at elevated temperatures, various metal/ligand/base combinations were evaluated for their ability to enable biaryl formation through C-H activation. The combination of cobalt(III) acetylacetonate and lithium bis(trimethylsilyl)amide was subjected to further process intensification at 200 °C (15 bar), allowing a significant reduction of the catalyst/base loading and a dramatic increase in catalytic efficiency (turnover frequency) by a factor of 1000 compared to traditional protocols. The high-throughput screening additionally identified novel nickel- and copper-based metal/ligand combinations that favored an amination pathway competing with C-H activation, with the addition of ligands, such as 1,10-phenanthroline, having a profound influence on the selectivity. In addition to metal-based catalysts, high-T/p process windows were also successfully applied to transition-metal-free systems, utilizing 1,10-phenanthroline as organocatalyst.","lang":"eng"}],"publication_identifier":{"eissn":["1521-3765"],"issn":["0947-6539"]},"publisher":"Wiley","issue":"16","status":"public","article_type":"original","extern":"1","oa_version":"None","citation":{"ieee":"B. Pieber, D. Cantillo, and C. O. Kappe, “Direct arylation of benzene with aryl bromides using high‐temperature/high‐pressure process windows: Expanding the scope of C-H activation chemistry,” <i>Chemistry – A European Journal</i>, vol. 18, no. 16. Wiley, pp. 5047–5055, 2012.","ama":"Pieber B, Cantillo D, Kappe CO. Direct arylation of benzene with aryl bromides using high‐temperature/high‐pressure process windows: Expanding the scope of C-H activation chemistry. <i>Chemistry – A European Journal</i>. 2012;18(16):5047-5055. doi:<a href=\"https://doi.org/10.1002/chem.201103748\">10.1002/chem.201103748</a>","ista":"Pieber B, Cantillo D, Kappe CO. 2012. Direct arylation of benzene with aryl bromides using high‐temperature/high‐pressure process windows: Expanding the scope of C-H activation chemistry. Chemistry – A European Journal. 18(16), 5047–5055.","short":"B. Pieber, D. Cantillo, C.O. Kappe, Chemistry – A European Journal 18 (2012) 5047–5055.","mla":"Pieber, Bartholomäus, et al. “Direct Arylation of Benzene with Aryl Bromides Using High‐temperature/High‐pressure Process Windows: Expanding the Scope of C-H Activation Chemistry.” <i>Chemistry – A European Journal</i>, vol. 18, no. 16, Wiley, 2012, pp. 5047–55, doi:<a href=\"https://doi.org/10.1002/chem.201103748\">10.1002/chem.201103748</a>.","chicago":"Pieber, Bartholomäus, David Cantillo, and C. Oliver Kappe. “Direct Arylation of Benzene with Aryl Bromides Using High‐temperature/High‐pressure Process Windows: Expanding the Scope of C-H Activation Chemistry.” <i>Chemistry – A European Journal</i>. Wiley, 2012. <a href=\"https://doi.org/10.1002/chem.201103748\">https://doi.org/10.1002/chem.201103748</a>.","apa":"Pieber, B., Cantillo, D., &#38; Kappe, C. O. (2012). Direct arylation of benzene with aryl bromides using high‐temperature/high‐pressure process windows: Expanding the scope of C-H activation chemistry. <i>Chemistry – A European Journal</i>. Wiley. <a href=\"https://doi.org/10.1002/chem.201103748\">https://doi.org/10.1002/chem.201103748</a>"},"type":"journal_article","date_created":"2022-08-24T12:48:28Z","article_processing_charge":"No","scopus_import":"1","title":"Direct arylation of benzene with aryl bromides using high‐temperature/high‐pressure process windows: Expanding the scope of C-H activation chemistry","date_updated":"2023-02-21T10:09:35Z","month":"04"}