{"article_type":"letter_note","extern":"1","status":"public","oa_version":"None","year":"2016","abstract":[{"lang":"eng","text":"A continuous process for the synthesis and inline separation of anhydrous trifluoromethyl diazomethane in a single continuous flow process is presented. The diazo building block is generated from the corresponding amine and NaNO2 under acidic, aqueous conditions and subsequently diffuses through a gas-permeable membrane into an organic stream. To avoid storage and transportation of the hazardous compound, a representative downstream process in a packed-bed reactor yielding highly functionalized building blocks was developed."}],"publication_identifier":{"eissn":["1523-7052"],"issn":["1523-7060"]},"publisher":"American Chemical Society","issue":"5","article_processing_charge":"No","scopus_import":"1","title":"Generation and synthetic application of trifluoromethyl diazomethane utilizing continuous flow technologies","month":"03","date_updated":"2023-02-21T10:10:21Z","citation":{"mla":"Pieber, Bartholomäus, and C. Oliver Kappe. “Generation and Synthetic Application of Trifluoromethyl Diazomethane Utilizing Continuous Flow Technologies.” <i>Organic Letters</i>, vol. 18, no. 5, American Chemical Society, 2016, pp. 1076–79, doi:<a href=\"https://doi.org/10.1021/acs.orglett.6b00194\">10.1021/acs.orglett.6b00194</a>.","ieee":"B. Pieber and C. O. Kappe, “Generation and synthetic application of trifluoromethyl diazomethane utilizing continuous flow technologies,” <i>Organic Letters</i>, vol. 18, no. 5. American Chemical Society, pp. 1076–1079, 2016.","ama":"Pieber B, Kappe CO. Generation and synthetic application of trifluoromethyl diazomethane utilizing continuous flow technologies. <i>Organic Letters</i>. 2016;18(5):1076-1079. doi:<a href=\"https://doi.org/10.1021/acs.orglett.6b00194\">10.1021/acs.orglett.6b00194</a>","short":"B. Pieber, C.O. Kappe, Organic Letters 18 (2016) 1076–1079.","ista":"Pieber B, Kappe CO. 2016. Generation and synthetic application of trifluoromethyl diazomethane utilizing continuous flow technologies. Organic Letters. 18(5), 1076–1079.","apa":"Pieber, B., &#38; Kappe, C. O. (2016). Generation and synthetic application of trifluoromethyl diazomethane utilizing continuous flow technologies. <i>Organic Letters</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.orglett.6b00194\">https://doi.org/10.1021/acs.orglett.6b00194</a>","chicago":"Pieber, Bartholomäus, and C. Oliver Kappe. “Generation and Synthetic Application of Trifluoromethyl Diazomethane Utilizing Continuous Flow Technologies.” <i>Organic Letters</i>. American Chemical Society, 2016. <a href=\"https://doi.org/10.1021/acs.orglett.6b00194\">https://doi.org/10.1021/acs.orglett.6b00194</a>."},"type":"journal_article","date_created":"2022-08-25T11:22:20Z","page":"1076-1079","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":"        18","quality_controlled":"1","language":[{"iso":"eng"}],"external_id":{"pmid":["26902154"]},"doi":"10.1021/acs.orglett.6b00194","author":[{"first_name":"Bartholomäus","orcid":"0000-0001-8689-388X","id":"93e5e5b2-0da6-11ed-8a41-af589a024726","full_name":"Pieber, Bartholomäus","last_name":"Pieber"},{"first_name":"C. Oliver","last_name":"Kappe","full_name":"Kappe, C. Oliver"}],"pmid":1,"volume":18,"_id":"11983","date_published":"2016-03-04T00:00:00Z","publication":"Organic Letters","day":"04","publication_status":"published"}