article Flash carboxylation: Fast lithiation–carboxylation sequence at room temperature in continuous flow published yes Bartholomäus Pieber author 93e5e5b2-0da6-11ed-8a41-af589a0247260000-0001-8689-388X Toma Glasnov author C. O. Kappe author A method for the direct lithiation of terminal alkynes and heterocycles with subsequent carboxylation in a continuous flow format was developed. This method provides carboxylic acids at ambient conditions within less than five seconds with only little excess of the organometallic base and CO2. Royal Society of Chemistry2014 eng RSC Advances 2046-206910.1039/c4ra01442a 426 yes B. Pieber, T. Glasnov, C.O. Kappe, RSC Advances 4 (2014). Pieber, B., Glasnov, T., &#38; Kappe, C. O. (2014). Flash carboxylation: Fast lithiation–carboxylation sequence at room temperature in continuous flow. <i>RSC Advances</i>. Royal Society of Chemistry. <a href="https://doi.org/10.1039/c4ra01442a">https://doi.org/10.1039/c4ra01442a</a> Pieber, Bartholomäus, Toma Glasnov, and C. O. Kappe. “Flash Carboxylation: Fast Lithiation–Carboxylation Sequence at Room Temperature in Continuous Flow.” <i>RSC Advances</i>. Royal Society of Chemistry, 2014. <a href="https://doi.org/10.1039/c4ra01442a">https://doi.org/10.1039/c4ra01442a</a>. Pieber B, Glasnov T, Kappe CO. 2014. Flash carboxylation: Fast lithiation–carboxylation sequence at room temperature in continuous flow. RSC Advances. 4(26), 13430. B. Pieber, T. Glasnov, and C. O. Kappe, “Flash carboxylation: Fast lithiation–carboxylation sequence at room temperature in continuous flow,” <i>RSC Advances</i>, vol. 4, no. 26. Royal Society of Chemistry, 2014. Pieber, Bartholomäus, et al. “Flash Carboxylation: Fast Lithiation–Carboxylation Sequence at Room Temperature in Continuous Flow.” <i>RSC Advances</i>, vol. 4, no. 26, 13430, Royal Society of Chemistry, 2014, doi:<a href="https://doi.org/10.1039/c4ra01442a">10.1039/c4ra01442a</a>. Pieber B, Glasnov T, Kappe CO. Flash carboxylation: Fast lithiation–carboxylation sequence at room temperature in continuous flow. <i>RSC Advances</i>. 2014;4(26). doi:<a href="https://doi.org/10.1039/c4ra01442a">10.1039/c4ra01442a</a> 119872022-08-25T11:48:19Z2023-02-21T10:10:31Z