---
_id: '11987'
abstract:
- lang: eng
  text: A method for the direct lithiation of terminal alkynes and heterocycles with
    subsequent carboxylation in a continuous flow format was developed. This method
    provides carboxylic acids at ambient conditions within less than five seconds
    with only little excess of the organometallic base and CO2.
article_number: '13430'
article_processing_charge: No
article_type: letter_note
author:
- first_name: Bartholomäus
  full_name: Pieber, Bartholomäus
  id: 93e5e5b2-0da6-11ed-8a41-af589a024726
  last_name: Pieber
  orcid: 0000-0001-8689-388X
- first_name: Toma
  full_name: Glasnov, Toma
  last_name: Glasnov
- first_name: C. O.
  full_name: Kappe, C. O.
  last_name: Kappe
citation:
  ama: 'Pieber B, Glasnov T, Kappe CO. Flash carboxylation: Fast lithiation–carboxylation
    sequence at room temperature in continuous flow. <i>RSC Advances</i>. 2014;4(26).
    doi:<a href="https://doi.org/10.1039/c4ra01442a">10.1039/c4ra01442a</a>'
  apa: 'Pieber, B., Glasnov, T., &#38; Kappe, C. O. (2014). Flash carboxylation: Fast
    lithiation–carboxylation sequence at room temperature in continuous flow. <i>RSC
    Advances</i>. Royal Society of Chemistry. <a href="https://doi.org/10.1039/c4ra01442a">https://doi.org/10.1039/c4ra01442a</a>'
  chicago: 'Pieber, Bartholomäus, Toma Glasnov, and C. O. Kappe. “Flash Carboxylation:
    Fast Lithiation–Carboxylation Sequence at Room Temperature in Continuous Flow.”
    <i>RSC Advances</i>. Royal Society of Chemistry, 2014. <a href="https://doi.org/10.1039/c4ra01442a">https://doi.org/10.1039/c4ra01442a</a>.'
  ieee: 'B. Pieber, T. Glasnov, and C. O. Kappe, “Flash carboxylation: Fast lithiation–carboxylation
    sequence at room temperature in continuous flow,” <i>RSC Advances</i>, vol. 4,
    no. 26. Royal Society of Chemistry, 2014.'
  ista: 'Pieber B, Glasnov T, Kappe CO. 2014. Flash carboxylation: Fast lithiation–carboxylation
    sequence at room temperature in continuous flow. RSC Advances. 4(26), 13430.'
  mla: 'Pieber, Bartholomäus, et al. “Flash Carboxylation: Fast Lithiation–Carboxylation
    Sequence at Room Temperature in Continuous Flow.” <i>RSC Advances</i>, vol. 4,
    no. 26, 13430, Royal Society of Chemistry, 2014, doi:<a href="https://doi.org/10.1039/c4ra01442a">10.1039/c4ra01442a</a>.'
  short: B. Pieber, T. Glasnov, C.O. Kappe, RSC Advances 4 (2014).
date_created: 2022-08-25T11:48:19Z
date_published: 2014-03-03T00:00:00Z
date_updated: 2023-02-21T10:10:31Z
day: '03'
doi: 10.1039/c4ra01442a
extern: '1'
intvolume: '         4'
issue: '26'
language:
- iso: eng
month: '03'
oa_version: None
publication: RSC Advances
publication_identifier:
  eissn:
  - 2046-2069
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Flash carboxylation: Fast lithiation–carboxylation sequence at room temperature
  in continuous flow'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2014'
...