---
res:
  bibo_abstract:
  - Regulation of chromatin states involves the dynamic interplay between different
    histone modifications to control gene expression. Recent advances have enabled
    mapping of histone marks in single cells, but most methods are constrained to
    profile only one histone mark per cell. Here, we present an integrated experimental
    and computational framework, scChIX-seq (single-cell chromatin immunocleavage
    and unmixing sequencing), to map several histone marks in single cells. scChIX-seq
    multiplexes two histone marks together in single cells, then computationally deconvolves
    the signal using training data from respective histone mark profiles. This framework
    learns the cell-type-specific correlation structure between histone marks, and
    therefore does not require a priori assumptions of their genomic distributions.
    Using scChIX-seq, we demonstrate multimodal analysis of histone marks in single
    cells across a range of mark combinations. Modeling dynamics of in vitro macrophage
    differentiation enables integrated analysis of chromatin velocity. Overall, scChIX-seq
    unlocks systematic interrogation of the interplay between histone modifications
    in single cells.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Jake
      foaf_name: Yeung, Jake
      foaf_surname: Yeung
      foaf_workInfoHomepage: http://www.librecat.org/personId=123012b2-db30-11eb-b4d8-a35840c0551b
    orcid: 0000-0003-1732-1559
  - foaf_Person:
      foaf_givenName: Maria
      foaf_name: Florescu, Maria
      foaf_surname: Florescu
  - foaf_Person:
      foaf_givenName: Peter
      foaf_name: Zeller, Peter
      foaf_surname: Zeller
  - foaf_Person:
      foaf_givenName: Buys Anton
      foaf_name: De Barbanson, Buys Anton
      foaf_surname: De Barbanson
  - foaf_Person:
      foaf_givenName: Max D.
      foaf_name: Wellenstein, Max D.
      foaf_surname: Wellenstein
  - foaf_Person:
      foaf_givenName: Alexander
      foaf_name: Van Oudenaarden, Alexander
      foaf_surname: Van Oudenaarden
  bibo_doi: 10.1038/s41587-022-01560-3
  bibo_volume: 41
  dct_date: 2023^xs_gYear
  dct_identifier:
  - UT:000909067600003
  dct_isPartOf:
  - http://id.crossref.org/issn/1087-0156
  - http://id.crossref.org/issn/1546-1696
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: scChIX-seq infers dynamic relationships between histone modifications
    in single cells@
  fabio_hasPubmedId: '36593403'
...