Mechanochemical rules for shape-shifting filaments that remodel membranes Meadowcroft, Billie ; https://orcid.org/0000-0003-3441-1337 Palaia, Ivan ; https://orcid.org/ 0000-0002-8843-9485 Pfitzner, Anna Katharina Roux, Aurélien Baum, Buzz Šarić, Anđela ; https://orcid.org/0000-0002-7854-2139 The sequential exchange of filament composition to increase filament curvature was proposed as a mechanism for how some biological polymers deform and cut membranes. The relationship between the filament composition and its mechanical effect is lacking. We develop a kinetic model for the assembly of composite filaments that includes protein–membrane adhesion, filament mechanics and membrane mechanics. We identify the physical conditions for such a membrane remodeling and show this mechanism of sequential polymer assembly lowers the energetic barrier for membrane deformation. American Physical Society 2022 info:eu-repo/semantics/article doc-type:article text http://purl.org/coar/resource_type/c_2df8fbb1 https://research-explorer.ista.ac.at/record/12108 Meadowcroft B, Palaia I, Pfitzner AK, Roux A, Baum B, Šarić A. Mechanochemical rules for shape-shifting filaments that remodel membranes. <i>Physical Review Letters</i>. 2022;129(26). doi:<a href="https://doi.org/10.1103/PhysRevLett.129.268101">10.1103/PhysRevLett.129.268101</a> eng info:eu-repo/semantics/altIdentifier/doi/10.1103/PhysRevLett.129.268101 info:eu-repo/semantics/altIdentifier/issn/0031-9007 info:eu-repo/semantics/altIdentifier/e-issn/1079-7114 info:eu-repo/semantics/altIdentifier/wos/000906721500001 info:eu-repo/semantics/altIdentifier/pmid/36608212 info:eu-repo/semantics/openAccess