article published yes Billie Meadowcroft author a4725fd6-932b-11ed-81e2-c098c7f37ae10000-0003-3441-1337 Ivan Palaia author 9c805cd2-4b75-11ec-a374-db6dd0ed57fa 0000-0002-8843-9485 Anna Katharina Pfitzner author Aurélien Roux author Buzz Baum author Anđela Šarić author bf63d406-f056-11eb-b41d-f263a6566d8b0000-0002-7854-2139 AnSa department IST-BRIDGE: International postdoctoral program project Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines project The evolution of trafficking: from archaea to eukaryotes project The sequential exchange of filament composition to increase filament curvature was proposed as a mechanism for how some biological polymers deform and cut membranes. The relationship between the filament composition and its mechanical effect is lacking. We develop a kinetic model for the assembly of composite filaments that includes protein–membrane adhesion, filament mechanics and membrane mechanics. We identify the physical conditions for such a membrane remodeling and show this mechanism of sequential polymer assembly lowers the energetic barrier for membrane deformation. American Physical Society2022 eng 0031-9007 1079-7114 36608212 00090672150000110.1103/PhysRevLett.129.268101 12926 Meadowcroft B, Palaia I, Pfitzner AK, Roux A, Baum B, Šarić A. Mechanochemical rules for shape-shifting filaments that remodel membranes. <i>Physical Review Letters</i>. 2022;129(26). doi:<a href="https://doi.org/10.1103/PhysRevLett.129.268101">10.1103/PhysRevLett.129.268101</a> Meadowcroft, B., Palaia, I., Pfitzner, A. K., Roux, A., Baum, B., &#38; Šarić, A. (2022). Mechanochemical rules for shape-shifting filaments that remodel membranes. <i>Physical Review Letters</i>. American Physical Society. <a href="https://doi.org/10.1103/PhysRevLett.129.268101">https://doi.org/10.1103/PhysRevLett.129.268101</a> Meadowcroft B, Palaia I, Pfitzner AK, Roux A, Baum B, Šarić A. 2022. Mechanochemical rules for shape-shifting filaments that remodel membranes. Physical Review Letters. 129(26), 268101. Meadowcroft, Billie, Ivan Palaia, Anna Katharina Pfitzner, Aurélien Roux, Buzz Baum, and Anđela Šarić. “Mechanochemical Rules for Shape-Shifting Filaments That Remodel Membranes.” <i>Physical Review Letters</i>. American Physical Society, 2022. <a href="https://doi.org/10.1103/PhysRevLett.129.268101">https://doi.org/10.1103/PhysRevLett.129.268101</a>. B. Meadowcroft, I. Palaia, A.K. Pfitzner, A. Roux, B. Baum, A. Šarić, Physical Review Letters 129 (2022). B. Meadowcroft, I. Palaia, A. K. Pfitzner, A. Roux, B. Baum, and A. Šarić, “Mechanochemical rules for shape-shifting filaments that remodel membranes,” <i>Physical Review Letters</i>, vol. 129, no. 26. American Physical Society, 2022. Meadowcroft, Billie, et al. “Mechanochemical Rules for Shape-Shifting Filaments That Remodel Membranes.” <i>Physical Review Letters</i>, vol. 129, no. 26, 268101, American Physical Society, 2022, doi:<a href="https://doi.org/10.1103/PhysRevLett.129.268101">10.1103/PhysRevLett.129.268101</a>. 121082023-01-08T23:00:53Z2025-04-14T07:54:53Z