---
_id: '12108'
abstract:
- lang: eng
  text: The sequential exchange of filament composition to increase filament curvature
    was proposed as a mechanism for how some biological polymers deform and cut membranes.
    The relationship between the filament composition and its mechanical effect is
    lacking. We develop a kinetic model for the assembly of composite filaments that
    includes protein–membrane adhesion, filament mechanics and membrane mechanics.
    We identify the physical conditions for such a membrane remodeling and show this
    mechanism of sequential polymer assembly lowers the energetic barrier for membrane
    deformation.
acknowledgement: "We thank T. C. T. Michaels and J. Palacci for useful discussions.
  We thank Claudia Flandoli for the illustrations in Fig. 1(b) and Fig. 2. We acknowledge
  funding by the European Union’s Horizon 2020 Research and Innovation Programme under
  the Marie Skłodowska-Curie Grant\r\nAgreement No. 101034413 (I. P.), the Royal Society
  Grant No. UF160266 (A. Š.), the European Research Council under the European Union’s
  Horizon 2020 Research and Innovation Programme (Grant No. 802960; B. M., I. P.,
  and A. Š.), and the Volkswagen Foundation\r\nLife Grant (B. B. and A. Š). "
article_number: '268101'
article_processing_charge: No
article_type: original
author:
- first_name: Billie
  full_name: Meadowcroft, Billie
  id: a4725fd6-932b-11ed-81e2-c098c7f37ae1
  last_name: Meadowcroft
  orcid: 0000-0003-3441-1337
- first_name: Ivan
  full_name: Palaia, Ivan
  id: 9c805cd2-4b75-11ec-a374-db6dd0ed57fa
  last_name: Palaia
  orcid: ' 0000-0002-8843-9485 '
- first_name: Anna Katharina
  full_name: Pfitzner, Anna Katharina
  last_name: Pfitzner
- first_name: Aurélien
  full_name: Roux, Aurélien
  last_name: Roux
- first_name: Buzz
  full_name: Baum, Buzz
  last_name: Baum
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
citation:
  ama: Meadowcroft B, Palaia I, Pfitzner AK, Roux A, Baum B, Šarić A. Mechanochemical
    rules for shape-shifting filaments that remodel membranes. <i>Physical Review
    Letters</i>. 2022;129(26). doi:<a href="https://doi.org/10.1103/PhysRevLett.129.268101">10.1103/PhysRevLett.129.268101</a>
  apa: Meadowcroft, B., Palaia, I., Pfitzner, A. K., Roux, A., Baum, B., &#38; Šarić,
    A. (2022). Mechanochemical rules for shape-shifting filaments that remodel membranes.
    <i>Physical Review Letters</i>. American Physical Society. <a href="https://doi.org/10.1103/PhysRevLett.129.268101">https://doi.org/10.1103/PhysRevLett.129.268101</a>
  chicago: Meadowcroft, Billie, Ivan Palaia, Anna Katharina Pfitzner, Aurélien Roux,
    Buzz Baum, and Anđela Šarić. “Mechanochemical Rules for Shape-Shifting Filaments
    That Remodel Membranes.” <i>Physical Review Letters</i>. American Physical Society,
    2022. <a href="https://doi.org/10.1103/PhysRevLett.129.268101">https://doi.org/10.1103/PhysRevLett.129.268101</a>.
  ieee: B. Meadowcroft, I. Palaia, A. K. Pfitzner, A. Roux, B. Baum, and A. Šarić,
    “Mechanochemical rules for shape-shifting filaments that remodel membranes,” <i>Physical
    Review Letters</i>, vol. 129, no. 26. American Physical Society, 2022.
  ista: Meadowcroft B, Palaia I, Pfitzner AK, Roux A, Baum B, Šarić A. 2022. Mechanochemical
    rules for shape-shifting filaments that remodel membranes. Physical Review Letters.
    129(26), 268101.
  mla: Meadowcroft, Billie, et al. “Mechanochemical Rules for Shape-Shifting Filaments
    That Remodel Membranes.” <i>Physical Review Letters</i>, vol. 129, no. 26, 268101,
    American Physical Society, 2022, doi:<a href="https://doi.org/10.1103/PhysRevLett.129.268101">10.1103/PhysRevLett.129.268101</a>.
  short: B. Meadowcroft, I. Palaia, A.K. Pfitzner, A. Roux, B. Baum, A. Šarić, Physical
    Review Letters 129 (2022).
corr_author: '1'
date_created: 2023-01-08T23:00:53Z
date_published: 2022-12-23T00:00:00Z
date_updated: 2025-04-14T07:54:53Z
day: '23'
department:
- _id: AnSa
doi: 10.1103/PhysRevLett.129.268101
ec_funded: 1
external_id:
  isi:
  - '000906721500001'
  pmid:
  - '36608212'
intvolume: '       129'
isi: 1
issue: '26'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: 'https://doi.org/10.1101/2022.05.10.490642 '
month: '12'
oa: 1
oa_version: Preprint
pmid: 1
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
  call_identifier: H2020
  grant_number: '802960'
  name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
- _id: eba0f67c-77a9-11ec-83b8-cc8501b3e222
  grant_number: '96752'
  name: 'The evolution of trafficking: from archaea to eukaryotes'
publication: Physical Review Letters
publication_identifier:
  eissn:
  - 1079-7114
  issn:
  - 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanochemical rules for shape-shifting filaments that remodel membranes
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 129
year: '2022'
...