{"department":[{"_id":"GaNo"}],"citation":{"mla":"Basilico, Bernadette, et al. “What Microglia Depletion Approaches Tell Us about the Role of Microglia on Synaptic Function and Behavior.” <i>Frontiers in Cellular Neuroscience</i>, vol. 16, 1022431, Frontiers Media, 2022, doi:<a href=\"https://doi.org/10.3389/fncel.2022.1022431\">10.3389/fncel.2022.1022431</a>.","apa":"Basilico, B., Ferrucci, L., Khan, A., Di Angelantonio, S., Ragozzino, D., &#38; Reverte, I. (2022). What microglia depletion approaches tell us about the role of microglia on synaptic function and behavior. <i>Frontiers in Cellular Neuroscience</i>. Frontiers Media. <a href=\"https://doi.org/10.3389/fncel.2022.1022431\">https://doi.org/10.3389/fncel.2022.1022431</a>","short":"B. Basilico, L. Ferrucci, A. Khan, S. Di Angelantonio, D. Ragozzino, I. Reverte, Frontiers in Cellular Neuroscience 16 (2022).","chicago":"Basilico, Bernadette, Laura Ferrucci, Azka Khan, Silvia Di Angelantonio, Davide Ragozzino, and Ingrid Reverte. “What Microglia Depletion Approaches Tell Us about the Role of Microglia on Synaptic Function and Behavior.” <i>Frontiers in Cellular Neuroscience</i>. Frontiers Media, 2022. <a href=\"https://doi.org/10.3389/fncel.2022.1022431\">https://doi.org/10.3389/fncel.2022.1022431</a>.","ama":"Basilico B, Ferrucci L, Khan A, Di Angelantonio S, Ragozzino D, Reverte I. What microglia depletion approaches tell us about the role of microglia on synaptic function and behavior. <i>Frontiers in Cellular Neuroscience</i>. 2022;16. doi:<a href=\"https://doi.org/10.3389/fncel.2022.1022431\">10.3389/fncel.2022.1022431</a>","ista":"Basilico B, Ferrucci L, Khan A, Di Angelantonio S, Ragozzino D, Reverte I. 2022. What microglia depletion approaches tell us about the role of microglia on synaptic function and behavior. Frontiers in Cellular Neuroscience. 16, 1022431.","ieee":"B. Basilico, L. Ferrucci, A. Khan, S. Di Angelantonio, D. Ragozzino, and I. Reverte, “What microglia depletion approaches tell us about the role of microglia on synaptic function and behavior,” <i>Frontiers in Cellular Neuroscience</i>, vol. 16. Frontiers Media, 2022."},"publication_status":"published","month":"11","type":"journal_article","acknowledgement":"The write-up of the review was supported by Sapienza University of Rome (Fondi di Ateneo, grant numbers #MA32117A7B698029 and #PH12017270934C3C to SD), Regione Lazio (POR FSE 2014/20, grant number #19036AP000000019 to SD), Fulbright 2019 (grant number\r\n#FSP-P005556 to SD), Institute Pasteur Italia (Fondi Cenci Bolognetti #363 to DR), and Network of European Funding for Neuroscience Research (ERA-NET NEURON Transnational\r\nResearch Projects on Neurodevelopmental Disorders 2021, grant acronym #JTC2021-SHANKAstro to DR).","intvolume":"        16","doi":"10.3389/fncel.2022.1022431","isi":1,"year":"2022","external_id":{"isi":["000886526600001"],"pmid":["36406752"]},"volume":16,"article_number":"1022431","date_updated":"2023-08-04T08:56:10Z","oa_version":"Published Version","file":[{"file_id":"12352","date_created":"2023-01-24T09:16:29Z","success":1,"creator":"dernst","relation":"main_file","date_updated":"2023-01-24T09:16:29Z","file_size":6399987,"checksum":"84696213ecf99182c58a9f34b9ff2e23","access_level":"open_access","file_name":"2022_FrontiersNeuroscience_Basilico.pdf","content_type":"application/pdf"}],"publication_identifier":{"issn":["1662-5102"]},"author":[{"orcid":"0000-0003-1843-3173","last_name":"Basilico","first_name":"Bernadette","id":"36035796-5ACA-11E9-A75E-7AF2E5697425","full_name":"Basilico, Bernadette"},{"full_name":"Ferrucci, Laura","first_name":"Laura","last_name":"Ferrucci"},{"full_name":"Khan, Azka","last_name":"Khan","first_name":"Azka"},{"full_name":"Di Angelantonio, Silvia","first_name":"Silvia","last_name":"Di Angelantonio"},{"last_name":"Ragozzino","first_name":"Davide","full_name":"Ragozzino, Davide"},{"full_name":"Reverte, Ingrid","first_name":"Ingrid","last_name":"Reverte"}],"date_published":"2022-11-04T00:00:00Z","language":[{"iso":"eng"}],"keyword":["Cellular and Molecular Neuroscience"],"article_processing_charge":"No","publisher":"Frontiers Media","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","status":"public","scopus_import":"1","has_accepted_license":"1","day":"04","file_date_updated":"2023-01-24T09:16:29Z","quality_controlled":"1","abstract":[{"text":"Microglia are dynamic cells, constantly surveying their surroundings and interacting with neurons and synapses. Indeed, a wealth of knowledge has revealed a critical role of microglia in modulating synaptic transmission and plasticity in the developing brain. In the past decade, novel pharmacological and genetic strategies have allowed the acute removal of microglia, opening the possibility to explore and understand the role of microglia also in the adult brain. In this review, we summarized and discussed the contribution of microglia depletion strategies to the current understanding of the role of microglia on synaptic function, learning and memory, and behavior both in physiological and pathological conditions. We first described the available microglia depletion methods highlighting their main strengths and weaknesses. We then reviewed the impact of microglia depletion on structural and functional synaptic plasticity. Next, we focused our analysis on the effects of microglia depletion on behavior, including general locomotor activity, sensory perception, motor function, sociability, learning and memory both in healthy animals and animal models of disease. Finally, we integrated the findings from the reviewed studies and discussed the emerging roles of microglia on the maintenance of synaptic function, learning, memory strength and forgetfulness, and the implications of microglia depletion in models of brain disease.","lang":"eng"}],"publication":"Frontiers in Cellular Neuroscience","_id":"12140","license":"https://creativecommons.org/licenses/by/4.0/","ddc":["570"],"title":"What microglia depletion approaches tell us about the role of microglia on synaptic function and behavior","article_type":"original","oa":1,"date_created":"2023-01-12T12:04:50Z","pmid":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"}}