---
res:
  bibo_abstract:
  - ESCRT-III filaments are composite cytoskeletal polymers that can constrict and
    cut cell membranes from the inside of the membrane neck. Membrane-bound ESCRT-III
    filaments undergo a series of dramatic composition and geometry changes in the
    presence of an ATP-consuming Vps4 enzyme, which causes stepwise changes in the
    membrane morphology. We set out to understand the physical mechanisms involved
    in translating the changes in ESCRT-III polymer composition into membrane deformation.
    We have built a coarse-grained model in which ESCRT-III polymers of different
    geometries and mechanical properties are allowed to copolymerise and bind to a
    deformable membrane. By modelling ATP-driven stepwise depolymerisation of specific
    polymers, we identify mechanical regimes in which changes in filament composition
    trigger the associated membrane transition from a flat to a buckled state, and
    then to a tubule state that eventually undergoes scission to release a small cargo-loaded
    vesicle. We then characterise how the location and kinetics of polymer loss affects
    the extent of membrane deformation and the efficiency of membrane neck scission.
    Our results identify the near-minimal mechanical conditions for the operation
    of shape-shifting composite polymers that sever membrane necks.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Xiuyun
      foaf_name: Jiang, Xiuyun
      foaf_surname: Jiang
  - foaf_Person:
      foaf_givenName: Lena
      foaf_name: Harker-Kirschneck, Lena
      foaf_surname: Harker-Kirschneck
  - foaf_Person:
      foaf_givenName: Christian Eduardo
      foaf_name: Vanhille-Campos, Christian Eduardo
      foaf_surname: Vanhille-Campos
      foaf_workInfoHomepage: http://www.librecat.org/personId=3adeca52-9313-11ed-b1ac-c170b2505714
  - foaf_Person:
      foaf_givenName: Anna-Katharina
      foaf_name: Pfitzner, Anna-Katharina
      foaf_surname: Pfitzner
  - foaf_Person:
      foaf_givenName: Elene
      foaf_name: Lominadze, Elene
      foaf_surname: Lominadze
  - foaf_Person:
      foaf_givenName: Aurélien
      foaf_name: Roux, Aurélien
      foaf_surname: Roux
  - foaf_Person:
      foaf_givenName: Buzz
      foaf_name: Baum, Buzz
      foaf_surname: Baum
  - foaf_Person:
      foaf_givenName: Anđela
      foaf_name: Šarić, Anđela
      foaf_surname: Šarić
      foaf_workInfoHomepage: http://www.librecat.org/personId=bf63d406-f056-11eb-b41d-f263a6566d8b
    orcid: 0000-0002-7854-2139
  bibo_doi: 10.1371/journal.pcbi.1010586
  bibo_issue: '10'
  bibo_volume: 18
  dct_date: 2022^xs_gYear
  dct_identifier:
  - UT:000924885500005
  dct_isPartOf:
  - http://id.crossref.org/issn/1553-7358
  dct_language: eng
  dct_publisher: Public Library of Science@
  dct_subject:
  - Computational Theory and Mathematics
  - Cellular and Molecular Neuroscience
  - Genetics
  - Molecular Biology
  - Ecology
  - Modeling and Simulation
  - Ecology
  - Evolution
  - Behavior and Systematics
  dct_title: Modelling membrane reshaping by staged polymerization of ESCRT-III filaments@
  fabio_hasPubmedId: '36251703'
...