---
res:
  bibo_abstract:
  - 'Post-translational histone modifications modulate chromatin activity to affect
    gene expression. How chromatin states underlie lineage choice in single cells
    is relatively unexplored. We develop sort-assisted single-cell chromatin immunocleavage
    (sortChIC) and map active (H3K4me1 and H3K4me3) and repressive (H3K27me3 and H3K9me3)
    histone modifications in the mouse bone marrow. During differentiation, hematopoietic
    stem and progenitor cells (HSPCs) acquire active chromatin states mediated by
    cell-type-specifying transcription factors, which are unique for each lineage.
    By contrast, most alterations in repressive marks during differentiation occur
    independent of the final cell type. Chromatin trajectory analysis shows that lineage
    choice at the chromatin level occurs at the progenitor stage. Joint profiling
    of H3K4me1 and H3K9me3 demonstrates that cell types within the myeloid lineage
    have distinct active chromatin but share similar myeloid-specific heterochromatin
    states. This implies a hierarchical regulation of chromatin during hematopoiesis:
    heterochromatin dynamics distinguish differentiation trajectories and lineages,
    while euchromatin dynamics reflect cell types within lineages.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Peter
      foaf_name: Zeller, Peter
      foaf_surname: Zeller
  - foaf_Person:
      foaf_givenName: Jake
      foaf_name: Yeung, Jake
      foaf_surname: Yeung
      foaf_workInfoHomepage: http://www.librecat.org/personId=123012b2-db30-11eb-b4d8-a35840c0551b
    orcid: 0000-0003-1732-1559
  - foaf_Person:
      foaf_givenName: Helena
      foaf_name: Viñas Gaza, Helena
      foaf_surname: Viñas Gaza
  - foaf_Person:
      foaf_givenName: Buys Anton
      foaf_name: de Barbanson, Buys Anton
      foaf_surname: de Barbanson
  - foaf_Person:
      foaf_givenName: Vivek
      foaf_name: Bhardwaj, Vivek
      foaf_surname: Bhardwaj
  - foaf_Person:
      foaf_givenName: Maria
      foaf_name: Florescu, Maria
      foaf_surname: Florescu
  - foaf_Person:
      foaf_givenName: Reinier
      foaf_name: van der Linden, Reinier
      foaf_surname: van der Linden
  - foaf_Person:
      foaf_givenName: Alexander
      foaf_name: van Oudenaarden, Alexander
      foaf_surname: van Oudenaarden
  bibo_doi: 10.1038/s41588-022-01260-3
  bibo_volume: 55
  dct_date: 2023^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/1061-4036
  - http://id.crossref.org/issn/1546-1718
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_subject:
  - Genetics
  dct_title: Single-cell sortChIC identifies hierarchical chromatin dynamics during
    hematopoiesis@
  fabio_hasPubmedId: '36539617'
...