---
res:
  bibo_abstract:
  - The term “haplotype block” is commonly used in the developing field of haplotype-based
    inference methods. We argue that the term should be defined based on the structure
    of the Ancestral Recombination Graph (ARG), which contains complete information
    on the ancestry of a sample. We use simulated examples to demonstrate key features
    of the relationship between haplotype blocks and ancestral structure, emphasizing
    the stochasticity of the processes that generate them. Even the simplest cases
    of neutrality or of a “hard” selective sweep produce a rich structure, often missed
    by commonly used statistics. We highlight a number of novel methods for inferring
    haplotype structure, based on the full ARG, or on a sequence of trees, and illustrate
    how they can be used to define haplotype blocks using an empirical data set. While
    the advent of new, computationally efficient methods makes it possible to apply
    these concepts broadly, they (and additional new methods) could benefit from adding
    features to explore haplotype blocks, as we define them. Understanding and applying
    the concept of the haplotype block will be essential to fully exploit long and
    linked-read sequencing technologies.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Daria
      foaf_name: Shipilina, Daria
      foaf_surname: Shipilina
      foaf_workInfoHomepage: http://www.librecat.org/personId=428A94B0-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-1145-9226
  - foaf_Person:
      foaf_givenName: Arka
      foaf_name: Pal, Arka
      foaf_surname: Pal
      foaf_workInfoHomepage: http://www.librecat.org/personId=6AAB2240-CA9A-11E9-9C1A-D9D1E5697425
    orcid: 0000-0002-4530-8469
  - foaf_Person:
      foaf_givenName: Sean
      foaf_name: Stankowski, Sean
      foaf_surname: Stankowski
      foaf_workInfoHomepage: http://www.librecat.org/personId=43161670-5719-11EA-8025-FABC3DDC885E
  - foaf_Person:
      foaf_givenName: Yingguang Frank
      foaf_name: Chan, Yingguang Frank
      foaf_surname: Chan
  - foaf_Person:
      foaf_givenName: Nicholas H
      foaf_name: Barton, Nicholas H
      foaf_surname: Barton
      foaf_workInfoHomepage: http://www.librecat.org/personId=4880FE40-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8548-5240
  bibo_doi: 10.1111/mec.16793
  bibo_issue: '6'
  bibo_volume: 32
  dct_date: 2023^xs_gYear
  dct_identifier:
  - UT:000900762000001
  dct_isPartOf:
  - http://id.crossref.org/issn/0962-1083
  - http://id.crossref.org/issn/1365-294X
  dct_language: eng
  dct_publisher: Wiley@
  dct_subject:
  - Genetics
  - Ecology
  - Evolution
  - Behavior and Systematics
  dct_title: On the origin and structure of haplotype blocks@
  fabio_hasPubmedId: '36433653'
...