---
res:
  bibo_abstract:
  - Meiotic crossovers (COs) are important for reshuffling genetic information between
    homologous chromosomes and they are essential for their correct segregation. COs
    are unevenly distributed along chromosomes and the underlying mechanisms controlling
    CO localization are not well understood. We previously showed that meiotic COs
    are mis-localized in the absence of AXR1, an enzyme involved in the neddylation/rubylation
    protein modification pathway in Arabidopsis thaliana. Here, we report that in
    axr1-/-, male meiocytes show a strong defect in chromosome pairing whereas the
    formation of the telomere bouquet is not affected. COs are also redistributed
    towards subtelomeric chromosomal ends where they frequently form clusters, in
    contrast to large central regions depleted in recombination. The CO suppressed
    regions correlate with DNA hypermethylation of transposable elements (TEs) in
    the CHH context in axr1-/- meiocytes. Through examining somatic methylomes, we
    found axr1-/- affects DNA methylation in a plant, causing hypermethylation in
    all sequence contexts (CG, CHG and CHH) in TEs. Impairment of the main pathways
    involved in DNA methylation is epistatic over axr1-/- for DNA methylation in somatic
    cells but does not restore regular chromosome segregation during meiosis. Collectively,
    our findings reveal that the neddylation pathway not only regulates hormonal perception
    and CO distribution but is also, directly or indirectly, a major limiting pathway
    of TE DNA methylation in somatic cells.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Nicolas
      foaf_name: Christophorou, Nicolas
      foaf_surname: Christophorou
  - foaf_Person:
      foaf_givenName: Wenjing
      foaf_name: She, Wenjing
      foaf_surname: She
  - foaf_Person:
      foaf_givenName: Jincheng
      foaf_name: Long, Jincheng
      foaf_surname: Long
  - foaf_Person:
      foaf_givenName: Aurélie
      foaf_name: Hurel, Aurélie
      foaf_surname: Hurel
  - foaf_Person:
      foaf_givenName: Sébastien
      foaf_name: Beaubiat, Sébastien
      foaf_surname: Beaubiat
  - foaf_Person:
      foaf_givenName: Yassir
      foaf_name: Idir, Yassir
      foaf_surname: Idir
  - foaf_Person:
      foaf_givenName: Marina
      foaf_name: Tagliaro-Jahns, Marina
      foaf_surname: Tagliaro-Jahns
  - foaf_Person:
      foaf_givenName: Aurélie
      foaf_name: Chambon, Aurélie
      foaf_surname: Chambon
  - foaf_Person:
      foaf_givenName: Victor
      foaf_name: Solier, Victor
      foaf_surname: Solier
  - foaf_Person:
      foaf_givenName: Daniel
      foaf_name: Vezon, Daniel
      foaf_surname: Vezon
  - foaf_Person:
      foaf_givenName: Mathilde
      foaf_name: Grelon, Mathilde
      foaf_surname: Grelon
  - foaf_Person:
      foaf_givenName: Xiaoqi
      foaf_name: Feng, Xiaoqi
      foaf_surname: Feng
      foaf_workInfoHomepage: http://www.librecat.org/personId=e0164712-22ee-11ed-b12a-d80fcdf35958
    orcid: 0000-0002-4008-1234
  - foaf_Person:
      foaf_givenName: Nicolas
      foaf_name: Bouché, Nicolas
      foaf_surname: Bouché
  - foaf_Person:
      foaf_givenName: Christine
      foaf_name: Mézard, Christine
      foaf_surname: Mézard
  bibo_doi: 10.1371/journal.pgen.1008894
  bibo_issue: '6'
  bibo_volume: 16
  dct_date: 2020^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/1553-7404
  dct_language: eng
  dct_publisher: Public Library of Science (PLoS)@
  dct_subject:
  - Cancer Research
  - Genetics (clinical)
  - Genetics
  - Molecular Biology
  - Ecology
  - Evolution
  - Behavior and Systematics
  dct_title: AXR1 affects DNA methylation independently of its role in regulating
    meiotic crossover localization@
  fabio_hasPubmedId: '32598340'
...