---
res:
  bibo_abstract:
  - Embryo development requires biochemical signalling to generate patterns of cell
    fates and active mechanical forces to drive tissue shape changes. However, how
    these processes are coordinated, and how tissue patterning is preserved despite
    the cellular flows occurring during morphogenesis, remains poorly understood.
    Gastrulation is a crucial embryonic stage that involves both patterning and internalization
    of the mesendoderm germ layer tissue. Here we show that, in zebrafish embryos,
    a gradient in Nodal signalling orchestrates pattern-preserving internalization
    movements by triggering a motility-driven unjamming transition. In addition to
    its role as a morphogen determining embryo patterning, graded Nodal signalling
    mechanically subdivides the mesendoderm into a small fraction of highly protrusive
    leader cells, able to autonomously internalize via local unjamming, and less protrusive
    followers, which need to be pulled inwards by the leaders. The Nodal gradient
    further enforces a code of preferential adhesion coupling leaders to their immediate
    followers, resulting in a collective and ordered mode of internalization that
    preserves mesendoderm patterning. Integrating this dual mechanical role of Nodal
    signalling into minimal active particle simulations quantitatively predicts both
    physiological and experimentally perturbed internalization movements. This provides
    a quantitative framework for how a morphogen-encoded unjamming transition can
    bidirectionally couple tissue mechanics with patterning during complex three-dimensional
    morphogenesis.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Diana C
      foaf_name: Nunes Pinheiro, Diana C
      foaf_surname: Nunes Pinheiro
      foaf_workInfoHomepage: http://www.librecat.org/personId=2E839F16-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-4333-7503
  - foaf_Person:
      foaf_givenName: Roland
      foaf_name: Kardos, Roland
      foaf_surname: Kardos
      foaf_workInfoHomepage: http://www.librecat.org/personId=4039350E-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Edouard B
      foaf_name: Hannezo, Edouard B
      foaf_surname: Hannezo
      foaf_workInfoHomepage: http://www.librecat.org/personId=3A9DB764-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6005-1561
  - foaf_Person:
      foaf_givenName: Carl-Philipp J
      foaf_name: Heisenberg, Carl-Philipp J
      foaf_surname: Heisenberg
      foaf_workInfoHomepage: http://www.librecat.org/personId=39427864-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-0912-4566
  bibo_doi: 10.1038/s41567-022-01787-6
  bibo_issue: '12'
  bibo_volume: 18
  dct_date: 2022^xs_gYear
  dct_identifier:
  - UT:000871319900002
  dct_isPartOf:
  - http://id.crossref.org/issn/1745-2473
  - http://id.crossref.org/issn/1745-2481
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_subject:
  - General Physics and Astronomy
  dct_title: Morphogen gradient orchestrates pattern-preserving tissue morphogenesis
    via motility-driven unjamming@
...