---
res:
  bibo_abstract:
  - Muskelin (Mkln1) is implicated in neuronal function, regulating plasma membrane
    receptor trafficking. However, its influence on intrinsic brain activity and corresponding
    behavioral processes remains unclear. Here we show that murine <jats:italic>Mkln1</jats:italic>
    knockout causes non-habituating locomotor activity, increased exploratory drive,
    and decreased locomotor response to amphetamine. Muskelin deficiency impairs social
    novelty detection while promoting the retention of spatial reference memory and
    fear extinction recall. This is strongly mirrored in either weaker or stronger
    resting-state functional connectivity between critical circuits mediating locomotor
    exploration and cognition. We show that <jats:italic>Mkln1</jats:italic> deletion
    alters dendrite branching and spine structure, coinciding with enhanced AMPAR-mediated
    synaptic transmission but selective impairment in synaptic potentiation maintenance.
    We identify muskelin at excitatory synapses and highlight its role in regulating
    dendritic spine actin stability. Our findings point to aberrant spine actin modulation
    and changes in glutamatergic synaptic function as critical mechanisms that contribute
    to the neurobehavioral phenotype arising from <jats:italic>Mkln1</jats:italic>
    ablation.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Mary W
      foaf_name: Muhia, Mary W
      foaf_surname: Muhia
      foaf_workInfoHomepage: http://www.librecat.org/personId=ab7ed20f-09f7-11eb-909c-d5d0b443ee9d
  - foaf_Person:
      foaf_givenName: PingAn
      foaf_name: YuanXiang, PingAn
      foaf_surname: YuanXiang
  - foaf_Person:
      foaf_givenName: Jan
      foaf_name: Sedlacik, Jan
      foaf_surname: Sedlacik
  - foaf_Person:
      foaf_givenName: Jürgen R.
      foaf_name: Schwarz, Jürgen R.
      foaf_surname: Schwarz
  - foaf_Person:
      foaf_givenName: Frank F.
      foaf_name: Heisler, Frank F.
      foaf_surname: Heisler
  - foaf_Person:
      foaf_givenName: Kira V.
      foaf_name: Gromova, Kira V.
      foaf_surname: Gromova
  - foaf_Person:
      foaf_givenName: Edda
      foaf_name: Thies, Edda
      foaf_surname: Thies
  - foaf_Person:
      foaf_givenName: Petra
      foaf_name: Breiden, Petra
      foaf_surname: Breiden
  - foaf_Person:
      foaf_givenName: Yvonne
      foaf_name: Pechmann, Yvonne
      foaf_surname: Pechmann
  - foaf_Person:
      foaf_givenName: Michael R.
      foaf_name: Kreutz, Michael R.
      foaf_surname: Kreutz
  - foaf_Person:
      foaf_givenName: Matthias
      foaf_name: Kneussel, Matthias
      foaf_surname: Kneussel
  bibo_doi: 10.1038/s42003-022-03446-1
  bibo_volume: 5
  dct_date: 2022^xs_gYear
  dct_identifier:
  - UT:000811777900003
  dct_isPartOf:
  - http://id.crossref.org/issn/2399-3642
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_subject:
  - General Agricultural and Biological Sciences
  - General Biochemistry
  - Genetics and Molecular Biology
  - Medicine (miscellaneous)
  dct_title: Muskelin regulates actin-dependent synaptic changes and intrinsic brain
    activity relevant to behavioral and cognitive processes@
...