---
res:
  bibo_abstract:
  - The AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis that initiates
    cytoplasmic maturation of the large ribosomal subunit. Drg1 releases the shuttling
    maturation factor Rlp24 from pre-60S particles shortly after nuclear export, a
    strict requirement for downstream maturation. The molecular mechanism of release
    remained elusive. Here, we report a series of cryo-EM structures that captured
    the extraction of Rlp24 from pre-60S particles by Saccharomyces cerevisiae Drg1.
    These structures reveal that Arx1 and the eukaryote-specific rRNA expansion segment
    ES27 form a joint docking platform that positions Drg1 for efficient extraction
    of Rlp24 from the pre-ribosome. The tips of the Drg1 N domains thereby guide the
    Rlp24 C terminus into the central pore of the Drg1 hexamer, enabling extraction
    by a hand-over-hand translocation mechanism. Our results uncover substrate recognition
    and processing by Drg1 step by step and provide a comprehensive mechanistic picture
    of the conserved modus operandi of AAA-ATPases.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Michael
      foaf_name: Prattes, Michael
      foaf_surname: Prattes
  - foaf_Person:
      foaf_givenName: Irina
      foaf_name: Grishkovskaya, Irina
      foaf_surname: Grishkovskaya
  - foaf_Person:
      foaf_givenName: Victor-Valentin
      foaf_name: Hodirnau, Victor-Valentin
      foaf_surname: Hodirnau
      foaf_workInfoHomepage: http://www.librecat.org/personId=3661B498-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Christina
      foaf_name: Hetzmannseder, Christina
      foaf_surname: Hetzmannseder
  - foaf_Person:
      foaf_givenName: Gertrude
      foaf_name: Zisser, Gertrude
      foaf_surname: Zisser
  - foaf_Person:
      foaf_givenName: Carolin
      foaf_name: Sailer, Carolin
      foaf_surname: Sailer
  - foaf_Person:
      foaf_givenName: Vasileios
      foaf_name: Kargas, Vasileios
      foaf_surname: Kargas
  - foaf_Person:
      foaf_givenName: Mathias
      foaf_name: Loibl, Mathias
      foaf_surname: Loibl
  - foaf_Person:
      foaf_givenName: Magdalena
      foaf_name: Gerhalter, Magdalena
      foaf_surname: Gerhalter
  - foaf_Person:
      foaf_givenName: Lisa
      foaf_name: Kofler, Lisa
      foaf_surname: Kofler
  - foaf_Person:
      foaf_givenName: Alan J.
      foaf_name: Warren, Alan J.
      foaf_surname: Warren
  - foaf_Person:
      foaf_givenName: Florian
      foaf_name: Stengel, Florian
      foaf_surname: Stengel
  - foaf_Person:
      foaf_givenName: David
      foaf_name: Haselbach, David
      foaf_surname: Haselbach
  - foaf_Person:
      foaf_givenName: Helmut
      foaf_name: Bergler, Helmut
      foaf_surname: Bergler
  bibo_doi: 10.1038/s41594-022-00832-5
  bibo_issue: '9'
  bibo_volume: 29
  dct_date: 2022^xs_gYear
  dct_identifier:
  - UT:000852942100004
  dct_isPartOf:
  - http://id.crossref.org/issn/1545-9993
  - http://id.crossref.org/issn/1545-9985
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_subject:
  - Molecular Biology
  - Structural Biology
  dct_title: Visualizing maturation factor extraction from the nascent ribosome by
    the AAA-ATPase Drg1@
  fabio_hasPubmedId: '36097293'
...