---
res:
  bibo_abstract:
  - N-glycans are molecularly diverse sugars borne by over 70% of proteins transiting
    the secretory pathway and have been implicated in protein folding, stability,
    and localization. Mutations in genes important for N-glycosylation result in congenital
    disorders of glycosylation that are often associated with intellectual disability.
    Here, we show that structurally distinct N-glycans regulate an extracellular protein
    complex involved in the patterning of somatosensory dendrites in Caenorhabditis
    elegans. Specifically, aman-2/Golgi alpha-mannosidase II, a conserved key enzyme
    in the biosynthesis of specific N-glycans, regulates the activity of the Menorin
    adhesion complex without obviously affecting the protein stability and localization
    of its components. AMAN-2 functions cell-autonomously to allow for decoration
    of the neuronal transmembrane receptor DMA-1/LRR-TM with the correct set of high-mannose/hybrid/paucimannose
    N-glycans. Moreover, distinct types of N-glycans on specific N-glycosylation sites
    regulate DMA-1/LRR-TM receptor function, which, together with three other extracellular
    proteins, forms the Menorin adhesion complex. In summary, specific N-glycan structures
    regulate dendrite patterning by coordinating the activity of an extracellular
    adhesion complex, suggesting that the molecular diversity of N-glycans can contribute
    to developmental specificity in the nervous system.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Maisha
      foaf_name: Rahman, Maisha
      foaf_surname: Rahman
  - foaf_Person:
      foaf_givenName: Nelson
      foaf_name: Ramirez, Nelson
      foaf_surname: Ramirez
      foaf_workInfoHomepage: http://www.librecat.org/personId=39831956-E4FE-11E9-85DE-0DC7E5697425
  - foaf_Person:
      foaf_givenName: Carlos A
      foaf_name: Diaz‐Balzac, Carlos A
      foaf_surname: Diaz‐Balzac
  - foaf_Person:
      foaf_givenName: Hannes E
      foaf_name: Bülow, Hannes E
      foaf_surname: Bülow
  bibo_doi: 10.15252/embr.202154163
  bibo_issue: '7'
  bibo_volume: 23
  dct_date: 2022^xs_gYear
  dct_identifier:
  - UT:000797302700001
  dct_isPartOf:
  - http://id.crossref.org/issn/1469-221X
  - http://id.crossref.org/issn/1469-3178
  dct_language: eng
  dct_publisher: Embo Press@
  dct_subject:
  - Genetics
  - Molecular Biology
  - Biochemistry
  dct_title: Specific N-glycans regulate an extracellular adhesion complex during
    somatosensory dendrite patterning@
  fabio_hasPubmedId: '35586945'
...